Stabilisation of metastable polymorphs: the case of paracetamol form III

Richard J. Telford, Colin C Seaton, Alexander Clout, Asma B. M. Buanz, Simon Gaisford, Gareth R. Williams, Timothy J. Prior, Chidera H. Okoye, Tasnim Munshi, Ian J. Scowan

Research output: Contribution to journalArticlepeer-review

Abstract

The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph.
Original languageEnglish
Pages (from-to)12028-12031
JournalChemical Communications
Volume52
Issue number81
DOIs
Publication statusPublished - 5 Aug 2016

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