STAT1 regulates p73-mediated Bax gene expression

Surinder M. Soond, Christopher Carroll, Paul A. Townsend, Emre Sayan, Gerry Melino, Iris Behrmann, Richard A. Knight, David S. Latchman, Anastasis Stephanou

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of transcription factors remains poorly understood. In this study, we found that STAT1 and TA-p73 can interact directly and that p73-mediated Bax promoter activity was observed to be reduced by STAT1 expression in a p53-independent manner for which STAT1 Tyrosine-701 and Serine-727 are key residues. This study presents the first report physically linking STAT1 and TA-p73 signalling and highlights the modulation of the Bax promoter in the context of IFN-γ stimulation. © 2007 Federation of European Biochemical Societies.
    Original languageEnglish
    Pages (from-to)1217-1226
    Number of pages9
    JournalFEBS Letters
    Volume581
    Issue number6
    DOIs
    Publication statusPublished - 20 Mar 2007

    Keywords

    • Bax
    • Interferon-gamma
    • p53
    • Signal transducer and activator of transcription 1
    • TA-p73

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