Static secondary ion mass spectrometry for biological and biomedical research

Nicholas P. Lockyer

doi:10.1385/1-59745-294-7:543

Static secondary ion mass spectrometry for biological and biomedical research

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Static secondary ion mass spectrometry (SSIMS) is a capable of providing detailed atomic and molecular characterization of the surface chemistry of biological and biomedical materials. The technique is particularly suited to the detection and imaging of small molecules such as membrane lipids, metabolites, and drugs. A limit of detection in the ppm range and spatial resolution

Original language	English
Title of host publication	Methods in Molecular Biology\|Methods Mol. Biol.
Subtitle of host publication	Electron Microscopy: Methods and Protocols
Place of Publication	Totowa, New Jersey
Publisher	Humana Press, Inc
Pages	543-567
Number of pages	24
Volume	369
Edition	2nd
DOIs	https://doi.org/10.1385/1-59745-294-7:543
Publication status	Published - 27 Feb 2007

Keywords

Biomaterials
Cellular analysis
Imaging
Mass spectrometry
Static SIMS
Tissue imaging
TOF-SIMS

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10.1385/1-59745-294-7:543

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abstract = "Static secondary ion mass spectrometry (SSIMS) is a capable of providing detailed atomic and molecular characterization of the surface chemistry of biological and biomedical materials. The technique is particularly suited to the detection and imaging of small molecules such as membrane lipids, metabolites, and drugs. A limit of detection in the ppm range and spatial resolution",

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AU - Lockyer, Nicholas P.

PY - 2007/2/27

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N2 - Static secondary ion mass spectrometry (SSIMS) is a capable of providing detailed atomic and molecular characterization of the surface chemistry of biological and biomedical materials. The technique is particularly suited to the detection and imaging of small molecules such as membrane lipids, metabolites, and drugs. A limit of detection in the ppm range and spatial resolution

AB - Static secondary ion mass spectrometry (SSIMS) is a capable of providing detailed atomic and molecular characterization of the surface chemistry of biological and biomedical materials. The technique is particularly suited to the detection and imaging of small molecules such as membrane lipids, metabolites, and drugs. A limit of detection in the ppm range and spatial resolution

KW - Biomaterials

KW - Cellular analysis

KW - Imaging

KW - Mass spectrometry

KW - Static SIMS

KW - Tissue imaging

KW - TOF-SIMS

U2 - 10.1385/1-59745-294-7:543

DO - 10.1385/1-59745-294-7:543

M3 - Chapter

VL - 369

SP - 543

EP - 567

BT - Methods in Molecular Biology|Methods Mol. Biol.

PB - Humana Press, Inc

CY - Totowa, New Jersey

ER -

Static secondary ion mass spectrometry for biological and biomedical research

Abstract

Keywords

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