Statin use and exacerbations in individuals with chronic obstructive pulmonary disease.

Truls S Ingebrigtsen, Jacob L Marott, Børge G Nordestgaard, Peter Lange, Jesper Hallas, Jørgen Vestbo

    Research output: Contribution to journalArticlepeer-review

    Abstract

    BACKGROUND: We tested the hypothesis that statin use in individuals with COPD is associated with a reduced risk of exacerbations. METHODS: We identified 5794 individuals with COPD and a measurement of C reactive protein (CRP) in the Copenhagen General Population Study (2003-2008). During 3 years of follow-up we recorded exacerbations with hospital admissions or oral corticosteroid treatment. In a nested case-control design, matching on age, gender, smoking, COPD severity and comorbidity, we estimated the association between statin use and exacerbations. In addition, we examined the association between statin use and high CRP (>3 mg/L), and the association between high CRP and exacerbations during follow-up. RESULTS: Statin use was associated with reduced odds of exacerbations in crude analysis, OR=0.68 (95% CI 0.51 to 0.91, p=0.01), as well as in multivariable conditional logistic regression analysis, OR=0.67 (0.48 to 0.92, p=0.01). However, in the subgroup with the most severe COPD and without cardiovascular comorbidity, we observed a null association between statin use and exacerbations, OR=1.1 (0.5 to 2.1, p=0.83). Furthermore, statin use was associated with reduced odds of a high CRP, OR=0.69 (0.56 to 0.85, p
    Original languageEnglish
    JournalThorax
    Volume70
    Issue number1
    DOIs
    Publication statusPublished - Jan 2015

    Keywords

    • COPD Pharmacology
    • COPD epidemiology
    • Systemic disease and lungs

    Fingerprint

    Dive into the research topics of 'Statin use and exacerbations in individuals with chronic obstructive pulmonary disease.'. Together they form a unique fingerprint.

    Cite this