Statistical mechanics of pluripotency

Ben D. Macarthur; Ihor R. Lemischka

doi:10.1016/j.cell.2013.07.024

Statistical mechanics of pluripotency

Ben D. Macarthur, Ihor R. Lemischka

Research output: Contribution to journal › Article › peer-review

Abstract

Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory. © 2013 Elsevier Inc.

Original language	English
Pages (from-to)	484-489
Number of pages	5
Journal	Cell
Volume	154
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2013.07.024
Publication status	Published - 1 Aug 2013

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10.1016/j.cell.2013.07.024

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abstract = "Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory. {\textcopyright} 2013 Elsevier Inc.",

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AB - Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory. © 2013 Elsevier Inc.

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Statistical mechanics of pluripotency

Abstract

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