Stem cell regeneration of degenerated intervertebral discs: Current status

Stephen M. Richardson; Judith A. Hoyland

doi:10.1007/s11916-008-0016-3

Stem cell regeneration of degenerated intervertebral discs: Current status

Stephen M. Richardson, Judith A. Hoyland

Research output: Contribution to journal › Article › peer-review

Abstract

Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there is a growing interest in the potential of cell-based tissue engineering strategies for regeneration of the damaged IVD. To achieve this, investigators are now focusing on the use of mesenchymal stem cells (MSCs), which offer several advantages over more mature cell types. A number of problems must be overcome for MSC-based IVD regeneration to be successful, including determining a method for the differentiation of stem cells into nucleus pulposus-like cells. Although this is still a relatively new field, it offers huge potential for the clinical treatment of IVD degeneration and LBP in the future. Copyright © 2008 by Current Medicine Group LLC.

Original language	English
Pages (from-to)	83-88
Number of pages	5
Journal	Current Pain and Headache Reports
Volume	12
Issue number	2
DOIs	https://doi.org/10.1007/s11916-008-0016-3
Publication status	Published - Apr 2008

Keywords

Animals
physiology: Bone Regeneration
Humans
pathology: Intervertebral Disk
pathology: Low Back Pain
pathology: Spinal Diseases
methods: Stem Cell Transplantation
cytology: Stem Cells

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10.1007/s11916-008-0016-3

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title = "Stem cell regeneration of degenerated intervertebral discs: Current status",

abstract = "Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there is a growing interest in the potential of cell-based tissue engineering strategies for regeneration of the damaged IVD. To achieve this, investigators are now focusing on the use of mesenchymal stem cells (MSCs), which offer several advantages over more mature cell types. A number of problems must be overcome for MSC-based IVD regeneration to be successful, including determining a method for the differentiation of stem cells into nucleus pulposus-like cells. Although this is still a relatively new field, it offers huge potential for the clinical treatment of IVD degeneration and LBP in the future. Copyright {\textcopyright} 2008 by Current Medicine Group LLC.",

keywords = "Animals, physiology: Bone Regeneration, Humans, pathology: Intervertebral Disk, pathology: Low Back Pain, pathology: Spinal Diseases, methods: Stem Cell Transplantation, cytology: Stem Cells",

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year = "2008",

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doi = "10.1007/s11916-008-0016-3",

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T1 - Stem cell regeneration of degenerated intervertebral discs: Current status

AU - Richardson, Stephen M.

AU - Hoyland, Judith A.

PY - 2008/4

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N2 - Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there is a growing interest in the potential of cell-based tissue engineering strategies for regeneration of the damaged IVD. To achieve this, investigators are now focusing on the use of mesenchymal stem cells (MSCs), which offer several advantages over more mature cell types. A number of problems must be overcome for MSC-based IVD regeneration to be successful, including determining a method for the differentiation of stem cells into nucleus pulposus-like cells. Although this is still a relatively new field, it offers huge potential for the clinical treatment of IVD degeneration and LBP in the future. Copyright © 2008 by Current Medicine Group LLC.

AB - Low back pain (LBP) is one of the most common musculoskeletal conditions, and intervertebral disc (IVD) degeneration is associated with most cases. Although many treatment options are available, they focus on the removal of symptoms rather than repair of the degenerate tissue. However, there is a growing interest in the potential of cell-based tissue engineering strategies for regeneration of the damaged IVD. To achieve this, investigators are now focusing on the use of mesenchymal stem cells (MSCs), which offer several advantages over more mature cell types. A number of problems must be overcome for MSC-based IVD regeneration to be successful, including determining a method for the differentiation of stem cells into nucleus pulposus-like cells. Although this is still a relatively new field, it offers huge potential for the clinical treatment of IVD degeneration and LBP in the future. Copyright © 2008 by Current Medicine Group LLC.

KW - Animals

KW - physiology: Bone Regeneration

KW - Humans

KW - pathology: Intervertebral Disk

KW - pathology: Low Back Pain

KW - pathology: Spinal Diseases

KW - methods: Stem Cell Transplantation

KW - cytology: Stem Cells

U2 - 10.1007/s11916-008-0016-3

DO - 10.1007/s11916-008-0016-3

M3 - Article

C2 - 18474185

SN - 1531-3433

VL - 12

SP - 83

EP - 88

JO - Current Pain and Headache Reports

JF - Current Pain and Headache Reports

IS - 2

ER -

Stem cell regeneration of degenerated intervertebral discs: Current status

Abstract

Keywords

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