Stem cell therapies for muscle disorders

Francesco S. Tedesco, Giulio Cossu

    Research output: Contribution to journalArticlepeer-review


    Purpose of Review: This review focuses on stem cell-based therapies to treat skeletal muscle disorders, with a special emphasis on muscular dystrophies. Recent Findings: We briefly review previous attempts at cell therapy by the use of donor myoblasts, explaining the likely reasons for the poor clinical results; we then describe the use of the same cells in current promising trials for localized treatments of different diseases of skeletal muscle. Moreover, we discuss important novel findings on muscle stem/progenitor cell biology and their promise for future clinical translation. Preclinical and clinical applications of novel myogenic stem/progenitor cells are also described. Summary: We summarize several ongoing clinical trials for different muscle disorders and the advances in the understanding of the biology of the myogenic progenitors used in such trials. On the basis of the currently available information, a prediction of developments in the field is proposed. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
    Original languageEnglish
    Pages (from-to)597-603
    Number of pages6
    JournalCurrent Opinion in Neurology
    Issue number5
    Publication statusPublished - Oct 2012


    • cell therapy
    • diseases of skeletal muscle
    • muscular dystrophy
    • myogenic stem/progenitor cells


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