An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles process.
Research Beacons, Institutes and Platforms
- Manchester Institute of Biotechnology
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Znabet, A. (Creator), Blanken, S. (Creator), Janssen, E. (Creator), De Kanter, F. J. J. (Creator), Helliwell, M. (Creator), Turner, N. (Creator), Ruijter, E. (Creator) & Orru, R. V. A. (Creator), Cambridge Crystallographic Data Centre, 14 Sept 2011