Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM)

Anila I. Khan; T. H Samuel Tan; Jason Micklefield

doi:10.1039/b518171b

Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM)

Anila I. Khan, T. H Samuel Tan, Jason Micklefield

Research output: Contribution to journal › Article › peer-review

Abstract

The introduction of (7′S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7′R)-methylation disrupts hybridisation significantly. © The Royal Society of Chemistry 2006.

Original language	English
Pages (from-to)	1436-1438
Number of pages	2
Journal	Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/b518171b
Publication status	Published - 2006

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title = "Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM)",

abstract = "The introduction of (7′S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7′R)-methylation disrupts hybridisation significantly. {\textcopyright} The Royal Society of Chemistry 2006.",

author = "Khan, {Anila I.} and Tan, {T. H Samuel} and Jason Micklefield",

year = "2006",

doi = "10.1039/b518171b",

language = "English",

pages = "1436--1438",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM)

AU - Khan, Anila I.

AU - Tan, T. H Samuel

AU - Micklefield, Jason

PY - 2006

Y1 - 2006

N2 - The introduction of (7′S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7′R)-methylation disrupts hybridisation significantly. © The Royal Society of Chemistry 2006.

AB - The introduction of (7′S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7′R)-methylation disrupts hybridisation significantly. © The Royal Society of Chemistry 2006.

U2 - 10.1039/b518171b

DO - 10.1039/b518171b

M3 - Article

SN - 1359-7345

SP - 1436

EP - 1438

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM)

Abstract

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