Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients

M. Roth; S. Rogers; S. S. Roberts; J. M. Boyle; Hj Muller; W. Weber

Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients

M. Roth, S. Rogers, S. S. Roberts, J. M. Boyle, Hj Muller, W. Weber

Research output: Contribution to journal › Article › peer-review

Abstract

We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.

Original language	English
Pages (from-to)	809-815
Number of pages	6
Journal	Anticancer Research
Volume	14
Issue number	3 A
Publication status	Published - 1994

Keywords

6-4 Photoproducts
Cancer
Chemotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients",

abstract = "We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.",

keywords = "6-4 Photoproducts, Cancer, Chemotherapy",

author = "M. Roth and S. Rogers and Roberts, {S. S.} and Boyle, {J. M.} and Hj Muller and W. Weber",

note = "UI - 94354609LA - engRN - 0 (Alkylating Agents)RN - 0 (Antineoplastic Agents)RN - 9007-49-2 (DNA)PT - Journal ArticleDA - 19940926IS - 0250-7005SB - IMCY - GREECEJC - 59L",

year = "1994",

language = "English",

volume = "14",

pages = "809--815",

journal = "Anticancer Research",

issn = "1791-7530",

publisher = "International Institute of Anticancer Research",

number = "3 A",

}

TY - JOUR

T1 - Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients

AU - Roth, M.

AU - Rogers, S.

AU - Roberts, S. S.

AU - Boyle, J. M.

AU - Muller, Hj

AU - Weber, W.

N1 - UI - 94354609LA - engRN - 0 (Alkylating Agents)RN - 0 (Antineoplastic Agents)RN - 9007-49-2 (DNA)PT - Journal ArticleDA - 19940926IS - 0250-7005SB - IMCY - GREECEJC - 59L

PY - 1994

Y1 - 1994

N2 - We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.

AB - We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.

KW - 6-4 Photoproducts

KW - Cancer

KW - Chemotherapy

M3 - Article

SN - 1791-7530

VL - 14

SP - 809

EP - 815

JO - Anticancer Research

JF - Anticancer Research

IS - 3 A

ER -

Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients

Abstract

Keywords

UN SDGs

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