Strategies for Evaluating Idiopathic Inflammatory Myopathy Disease Susceptibility Genes

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    Abstract

    This review outlines the progress that has been made in understanding the genetics of the idiopathic inflammatory myopathies in the previous 2 years, with a particular focus on dermatomyositis and polymyositis. A recent genome-wide association study in dermatomyositis has confirmed the importance of the major histocompatibility region in this disease, and has suggested a shared genetic etiology with other autoimmune disorders. This has led to an ongoing study of additional immune-related loci using the Immunochip array. Candidate gene studies have identified novel risk associations in non-Europeans, such as STAT4 and HLA-DRB1 in the Japanese population. Evidence for gene-environment interactions has come from two recent studies implicating smoking status and statin use with HLA alleles. This review also touches on future approaches to genetic research in myositis, including bioinformatics tools to identify causal variants, HLA imputation from existing genetic data and statistical methods to investigate shared effects between subgroups of myositis. © 2014 Springer Science+Business Media New York.
    Original languageEnglish
    JournalCurrent Rheumatology Reports
    Volume16
    Issue number10
    DOIs
    Publication statusPublished - 3 Sept 2014

    Keywords

    • Candidate gene
    • Dermatomyositis
    • Gene-environment interaction
    • Genetics
    • Genome-wide association study
    • Idiopathic inflammatory myopathies
    • Myositis

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