Strategy to introduce an hydroxyapatite-keratin nanocomposite into a fibrous membrane for bone tissue engineering

Jiashen Li; J S Li; Y Li; X Liu; J Zhang; Y Zhang

doi:10.1039/c2tb00460g

Strategy to introduce an hydroxyapatite-keratin nanocomposite into a fibrous membrane for bone tissue engineering

Jiashen Li, J S Li, Y Li, X Liu, J Zhang, Y Zhang

The University of Manchester

Research output: Contribution to journal › Article › peer-review

Abstract

An hydroxyapatite (HA)-keratin nanocomposite was introduced into an electrospun poly(L-lactic acid) (PLLA) fibrous membrane with good electrospinnability. Biological in vitro cell culture demonstrated that the incorporation of HA-keratin into PLLA fibers led to significant bone formation compared to that of the pure electrospun PLLA membrane.

Original language	English
Pages (from-to)	432-437
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	1
Issue number	4
DOIs	https://doi.org/10.1039/c2tb00460g https://doi.org/Doi 10.1039/C2tb00460g
Publication status	Published - 2013

Keywords

osteoblast adhesion
progenitor cells
acid) scaffolds
wool keratin
nanofibers
collagen
regeneration
differentiation
mineralization
proliferation

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Cite this

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title = "Strategy to introduce an hydroxyapatite-keratin nanocomposite into a fibrous membrane for bone tissue engineering",

abstract = "An hydroxyapatite (HA)-keratin nanocomposite was introduced into an electrospun poly(L-lactic acid) (PLLA) fibrous membrane with good electrospinnability. Biological in vitro cell culture demonstrated that the incorporation of HA-keratin into PLLA fibers led to significant bone formation compared to that of the pure electrospun PLLA membrane.",

keywords = "osteoblast adhesion, progenitor cells, acid) scaffolds, wool keratin, nanofibers, collagen, regeneration, differentiation, mineralization, proliferation",

author = "Jiashen Li and Li, {J S} and Y Li and X Liu and J Zhang and Y Zhang",

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AU - Li, Jiashen

AU - Li, J S

AU - Li, Y

AU - Liu, X

AU - Zhang, J

AU - Zhang, Y

N1 - 087UH Times Cited:0 Cited References Count:35

PY - 2013

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AB - An hydroxyapatite (HA)-keratin nanocomposite was introduced into an electrospun poly(L-lactic acid) (PLLA) fibrous membrane with good electrospinnability. Biological in vitro cell culture demonstrated that the incorporation of HA-keratin into PLLA fibers led to significant bone formation compared to that of the pure electrospun PLLA membrane.

KW - osteoblast adhesion

KW - progenitor cells

KW - acid) scaffolds

KW - wool keratin

KW - nanofibers

KW - collagen

KW - regeneration

KW - differentiation

KW - mineralization

KW - proliferation

U2 - 10.1039/c2tb00460g

DO - 10.1039/c2tb00460g

M3 - Article

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EP - 437

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 4

ER -

Strategy to introduce an hydroxyapatite-keratin nanocomposite into a fibrous membrane for bone tissue engineering

Abstract

Keywords

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