@article{d5f330f5a1b74b9ca5b0972df75828f5,
title = "Streamlined Synthesis of C(sp3)-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysis",
abstract = "We report a general visible-light-mediated strategy that enables the construction of complex C(sp3)-rich N-heterospirocycles from feedstock aliphatic ketones and aldehydes with a broad selection of alkene-containing secondary amines. Key to the success of this approach was the utilization of a highly reducing Ir-photocatalyst and orchestration of the intrinsic reactivities of 1,4-cyclohexadiene and Hantzsch ester. This methodology provides streamlined access to complex C(sp3)-rich N-heterospirocycles displaying structural and functional features relevant to fragment-based lead identification programs.",
author = "Flod{\'e}n, {Nils J.} and Aaron Trowbridge and Darren Willcox and Walton, {Scarlett M.} and Yongjoon Kim and Gaunt, {Matthew J.}",
note = "Funding Information: We are grateful to the Gates Cambridge Trust (N.J.F.) and Herchel Smith Scholarship Scheme (A.T.) for studentships, the EPSRC (EP/S020292/1 and EP/N031792/1), Ambitious Leader{\textquoteright}s Program, Hokkaido University, Japan (Y.K.), and the Royal Society for a Wolfson Merit Award (M.J.G.). S.M.W. is a Fellow of the AstraZeneca Postdoctoral program. We are grateful to the EPSRC UK National Mass Spectrometry Facility at Swansea University for HRMS analysis. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = may,
day = "29",
doi = "10.1021/jacs.9b03372",
language = "English",
volume = "141",
pages = "8426--8430",
journal = "American Chemical Society. Journal ",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "21",
}