Streptozotocin: Inherent but not expressed skin sensitizing activity

J. Ashby, J. Hilton, R. J. Dearman, I. Kimber

    Research output: Contribution to journalArticlepeer-review


    We have shown previously that the alkylating agent streptozotocin (STZ) fails to induce responses in the murine local lymph node assay, a predictive test for contact sensitizing potential. In the present study, we demonstrate that this same compound when injected intradermally into the ears of mice provokes a dose-dependent induction of draining lymph node cell proliferation. These data indicate that the intrinsic immunogenicity of STZ is not displayed in the local lymph node assay under conditions of conventional topical exposure, secondary to a failure to cross the lipophilic stratum corneum in sufficient quantities. This finding has implications for the discernment of structure-activity relationships in contact sensitization.
    Original languageEnglish
    Pages (from-to)165-167
    Number of pages2
    JournalContact dermatitis
    Issue number3
    Publication statusPublished - 1995


    • Intradermal administration
    • Local lymph node assay
    • Mouse sensitization
    • Partition coefficient
    • Streptozotocin


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