Striving to cure adult T-cell leukaemia/lymphoma: A role for allogeneic stem cell transplant

E.H. Phillips, A. Hodson, O. Hermine, A. Bazarbachi, K. Cwynarski

Research output: Contribution to journalReview articlepeer-review

Abstract

Adult T-cell leukaemia/lymphoma (ATL) is an aggressive HTLV-1-related malignancy, rare outside of regions where the retrovirus is endemic. Although the use of antiviral therapy has improved outcomes, particularly for indolent forms of ATL, response to combination chemotherapy is poor and outcomes for aggressive subtypes remains dismal. Consolidation with allogeneic stem cell transplant (alloSCT) has an increasing role in the management of ATL in eligible patients, offering favourable long-term remission rates. However, relatively high-transplant-related mortality and issues with donor recruitment for certain ethnicities remain problematic. In this review, we discuss the rationale for and issues surrounding alloSCT in ATL in the context of conventional and emerging therapies.
Original languageEnglish
JournalBone Marrow Transplantation
DOIs
Publication statusPublished - 12 Sept 2016

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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