TY - JOUR
T1 - Strong, specific, reversible binding ligands for transfer RNA
T2 - Comparison by fluorescence and NMR spectroscopies with distamycin binding for a new structural class of ligand
AU - Bichenkova, Elena V.
AU - Sadat-Ebrahimi, Seyed E.
AU - Wilton, Amanda N.
AU - O'Toole, Niamh
AU - Marks, Debora S.
AU - Douglas, Kenneth T.
PY - 1998
Y1 - 1998
N2 - Binding data are presented for the interaction with brewer's yeast tRNA(Phe) of a new structural family of ligands, symmetrical bis- benzimidazoles. In addition specific perturbations in chemical shifts were detected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNA(Phe) when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added distamycin was followed fluorescence spectroscopy.
AB - Binding data are presented for the interaction with brewer's yeast tRNA(Phe) of a new structural family of ligands, symmetrical bis- benzimidazoles. In addition specific perturbations in chemical shifts were detected by 1-dimensional NMR spectroscopy at 400 MHz for some imino and aromatic methyl protons of tRNA(Phe) when the tRNA was titrated with distamycin. Competitive displacement of the benzimidazole by added distamycin was followed fluorescence spectroscopy.
UR - http://www.scopus.com/inward/record.url?scp=0031759525&partnerID=8YFLogxK
U2 - 10.1080/07328319808004698
DO - 10.1080/07328319808004698
M3 - Article
AN - SCOPUS:0031759525
SN - 0732-8311
VL - 17
SP - 1651
EP - 1665
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
IS - 9-11
ER -