Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis

Kirsty J. McLean; Andrew W. Munro

doi:10.1080/03602530802186389

Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis

Kirsty J. McLean, Andrew W. Munro

Research output: Contribution to journal › Article › peer-review

Abstract

The global spread of tuberculosis (TB) has been fuelled by the development of strains of the causative bacterium (Mycobacterium tuberculosis, Mtb) that are resistant to all the leading drugs. New TB therapies are desperately needed, but recent genome sequence, genetic and protein characterization studies have helped identify novel Mtb drug targets and key biochemical pathways for strategic intervention. Of particular interest are the multiple cytochrome P450 (P450) enzymes encoded in the Mtb genome. Structural, biochemical and mechanistic studies on these systems have demonstrated their potential as antitubercular targets, as well as revealing novel aspects of P450 form and function. Copyright © Informa UK, Ltd.

Original language	English
Pages (from-to)	427-446
Number of pages	19
Journal	Drug Metabolism Reviews
Volume	40
Issue number	3
DOIs	https://doi.org/10.1080/03602530802186389
Publication status	Published - Jul 2008

Keywords

Antitubercular therapy
Azole drugs
Cytochrome P450
Enzyme mechanism
Mycobacterium tuberculosis
Protein structure

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/03602530802186389

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title = "Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis",

abstract = "The global spread of tuberculosis (TB) has been fuelled by the development of strains of the causative bacterium (Mycobacterium tuberculosis, Mtb) that are resistant to all the leading drugs. New TB therapies are desperately needed, but recent genome sequence, genetic and protein characterization studies have helped identify novel Mtb drug targets and key biochemical pathways for strategic intervention. Of particular interest are the multiple cytochrome P450 (P450) enzymes encoded in the Mtb genome. Structural, biochemical and mechanistic studies on these systems have demonstrated their potential as antitubercular targets, as well as revealing novel aspects of P450 form and function. Copyright {\textcopyright} Informa UK, Ltd.",

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AU - Munro, Andrew W.

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AB - The global spread of tuberculosis (TB) has been fuelled by the development of strains of the causative bacterium (Mycobacterium tuberculosis, Mtb) that are resistant to all the leading drugs. New TB therapies are desperately needed, but recent genome sequence, genetic and protein characterization studies have helped identify novel Mtb drug targets and key biochemical pathways for strategic intervention. Of particular interest are the multiple cytochrome P450 (P450) enzymes encoded in the Mtb genome. Structural, biochemical and mechanistic studies on these systems have demonstrated their potential as antitubercular targets, as well as revealing novel aspects of P450 form and function. Copyright © Informa UK, Ltd.

KW - Antitubercular therapy

KW - Azole drugs

KW - Cytochrome P450

KW - Enzyme mechanism

KW - Mycobacterium tuberculosis

KW - Protein structure

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JF - Drug Metabolism Reviews

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ER -

Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis

Abstract

Keywords

UN SDGs

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