Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 2.

Bénédicte Delouvrié, Katherine Al-Kadhimi, Jean-Claude Arnould, Simon T Barry, Darren A E Cross, Myriam Didelot, Paul R Gavine, Hervé Germain, Craig S Harris, Adina M Hughes, David A Jude, Jane Kendrew, Christine Lambert-van der Brempt, Jean-Jacques Lohmann, Morgan Ménard, Andrew A Mortlock, Martin Pass, Claire Rooney, Michel Vautier, Jennifer L VincentNicolas Warin

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Potent antagonists of the integrin α(5)β(1), which are RGD mimetics built from tyrosine are described. This paper describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the central aromatic core and the amide moiety.
    Original languageEnglish
    JournalBioorganic & medicinal chemistry letters
    Volume22
    Issue number12
    DOIs
    Publication statusPublished - 15 Jun 2012

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