Structure-activity relationships of anti-HIV-1 N-alkoxy- and N-allyloxy-benzimidazoles.

Tahnee M. Evans; John M. Gardiner; Naheed Mahmood; Marilyne Smis

doi:10.1016/S0960-894X(97)00022-X

Structure-activity relationships of anti-HIV-1 N-alkoxy- and N-allyloxy-benzimidazoles.

Tahnee M. Evans, John M. Gardiner, Naheed Mahmood, Marilyne Smis

Research output: Contribution to journal › Article › peer-review

Abstract

One-pot benzimidazole syntheses have been used to prepare an extended series of novel analogues which were evaluated against HIV-1 infectivity, the most active having an EC50 of 0.5pM. There is a correlation between the length of saturated alkyl groups at O1 and C2 with antiviral selectivity. Replacing vinyl by the 2,2-dimethylvinyI group increases antiviral selectivity.

Original language	English
Pages (from-to)	409-412
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(97)00022-X
Publication status	Published - 18 Feb 1997

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10.1016/S0960-894X(97)00022-X

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title = "Structure-activity relationships of anti-HIV-1 N-alkoxy- and N-allyloxy-benzimidazoles.",

abstract = "One-pot benzimidazole syntheses have been used to prepare an extended series of novel analogues which were evaluated against HIV-1 infectivity, the most active having an EC50 of 0.5pM. There is a correlation between the length of saturated alkyl groups at O1 and C2 with antiviral selectivity. Replacing vinyl by the 2,2-dimethylvinyI group increases antiviral selectivity.",

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AU - Mahmood, Naheed

AU - Smis, Marilyne

PY - 1997/2/18

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AB - One-pot benzimidazole syntheses have been used to prepare an extended series of novel analogues which were evaluated against HIV-1 infectivity, the most active having an EC50 of 0.5pM. There is a correlation between the length of saturated alkyl groups at O1 and C2 with antiviral selectivity. Replacing vinyl by the 2,2-dimethylvinyI group increases antiviral selectivity.

U2 - 10.1016/S0960-894X(97)00022-X

DO - 10.1016/S0960-894X(97)00022-X

M3 - Article

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EP - 412

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Structure-activity relationships of anti-HIV-1 N-alkoxy- and N-allyloxy-benzimidazoles.

Abstract

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