Structure and chromosomal location of mouse and human CD52 genes

M. Tone, K. F. Nolan, L. A. Walsh, Y. Tone, S. A J Thompson, H. Waldmann

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Human CD52 (CAMPATH-1 antigen) is an abundant surface molecule on lymphocytes and a favoured target for lymphoma therapy and immunosuppression. It comprises a small glycosylphosphatidylinositol (GPI) anchored peptide to which a large carbohydrate moiety is attached. Structurally similar proteins include the proposed mouse homologue, B7 antigen (B7-Ag; not to be confused with the CD28 ligand), and human and mouse CD24. Sequence similarities between CD52 and B7-Ag precursors are concentrated over the signal peptides and the sequences cleaved during GPI attachment. While the short mature peptides are not apparently homologous, the N-linked glycosylation site is retained in both. We describe similarities in exon-intron organisation, syntenic chromosome positions (human CD52, 1p36; mouse B7-Ag, chromosome 4, between Dsi1 and D4Nds16) and sequence homology in the promoter regions which strongly suggests that B7-Ag is the mouse homologue of CD52. The structure of these genes is also similar to that of mouse CD24, suggesting a common ancestor. Promoter activities and transcription start sites were also analysed. These results suggest that human CD52 and mouse B7-Ag gene expressions are controlled by TATA-less promoters. Copyright (C) 1999 Elsevier Science B.V.
    Original languageEnglish
    Pages (from-to)334-340
    Number of pages6
    JournalBBA - Gene Structure and Expression
    Volume1446
    Issue number3
    Publication statusPublished - 1999

    Keywords

    • CAMPATH-1
    • CD24
    • CD52
    • Chromosomal location
    • Gene structure

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