Studies on liver chromatin from rats treated with dimethylnitrosamine

Helen K. Cooper; Ruth F. Itzhaki

Studies on liver chromatin from rats treated with dimethylnitrosamine

Helen K. Cooper
, Ruth F. Itzhaki

Research output: Contribution to journal › Article › peer-review

Abstract

Shortly after injecting a single low dose of N,N-dimethylnitrosamine into rats, the DNA, RNA and histones are methylated, the level in the DNA greatly exceeding that in the histones. The composition of the chromatin and the electrophoretic profiles of the histone and non-histone proteins are not detectably different from those obtained from control animals. Electric birefringence studies suggest that methylation may result in both interparticle cross-linking and some localised loosening of the DNA · protein complex. © 1975.

Original language	English
Pages (from-to)	263-272
Number of pages	9
Journal	BBA Section Nucleic Acids And Protein Synthesis
Volume	407
Issue number	3
Publication status	Published - 15 Oct 1975

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title = "Studies on liver chromatin from rats treated with dimethylnitrosamine",

abstract = "Shortly after injecting a single low dose of N,N-dimethylnitrosamine into rats, the DNA, RNA and histones are methylated, the level in the DNA greatly exceeding that in the histones. The composition of the chromatin and the electrophoretic profiles of the histone and non-histone proteins are not detectably different from those obtained from control animals. Electric birefringence studies suggest that methylation may result in both interparticle cross-linking and some localised loosening of the DNA · protein complex. {\textcopyright} 1975.",

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AU - Itzhaki, Ruth F.

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AB - Shortly after injecting a single low dose of N,N-dimethylnitrosamine into rats, the DNA, RNA and histones are methylated, the level in the DNA greatly exceeding that in the histones. The composition of the chromatin and the electrophoretic profiles of the histone and non-histone proteins are not detectably different from those obtained from control animals. Electric birefringence studies suggest that methylation may result in both interparticle cross-linking and some localised loosening of the DNA · protein complex. © 1975.

M3 - Article

C2 - 1186170

SN - 0005-2787

VL - 407

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EP - 272

JO - BBA Section Nucleic Acids And Protein Synthesis

JF - BBA Section Nucleic Acids And Protein Synthesis

IS - 3

ER -

Studies on liver chromatin from rats treated with dimethylnitrosamine

Abstract

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