TY - JOUR
T1 - Subclinical Inflammation of the Ocular Surface in Soft Contact Lens Wear
AU - Saliman, Noor Haziq
AU - Morgan, Philip B
AU - MacDonald, Andrew S
AU - Maldonado-Codina, Carole
N1 - Funding Information:
Received for publication April 26, 2019; revision received September 13, 2019; accepted September 17, 2019. Published online ahead of print November 7, 2019. From the Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom. This study was funded by the Malaysian government postgraduate scholar-ship (Majlis Amanah Rakyat). The authors have no conflicts of interest to disclose. Correspondence: Carole Maldonado-Codina, PhD, Carys Bannister Building, The University of Manchester, Dover St, Manchester M13 9PL, United Kingdom (e-mail: [email protected]). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Purpose: To investigate the inflammatory response of the ocular surface with different soft contact lens (CL) replacement frequencies and materials. Methods: Twenty soft CL wearers were required to wear 3 lens types: reusable Acuvue 2 (A2), reusable Acuvue Oasys (AO), and daily disposable Acuvue Oasys (AODD), for 1 week in random sequence in 1 eye with the nonlens-wearing eye acting as a control. Three methods were used to assess the subclinical response: tear cytokine evaluation, in vivo confocal microscopy (IVCM), and impression cytology. Results: Of 13 cytokines investigated, differences were observed only for IL-12p70, which was present in greater concentrations for A2 (interocular difference 8.8 pg/mL, 95% confidence interval 5.5–12.1) and AO (8.9 [5.7–12.1]) compared with AODD (3.7 [0.6–6.8]). For IVCM, corneal presumed dendritic cell density was lower for AODD (interocular difference 1.9 [20.1 to 3.9] cells/mm 2) than for both A2 (9.3 [7.2–11.4]) and AO (10.6 [8.6–12.6]). This trend was the same for the other 5 IVCM measures evaluated. The proportion of CD45 + cells in the bulbar conjunctiva was lower for AODD (0.6 [20.3 to 1.5]%) compared with A2 (4.6 [3.7–5.6]) and AO (4.8 [3.9–5.8]). Similar findings were observed for cells in the upper lid margin. Conclusions: This work has demonstrated for the first time that daily disposable CL wear produces a minimal subclinical inflammatory response compared with no lens wear over 1 week. By contrast, this inflammatory response is upregulated with reusable lenses but appears to be similar between hydrogel and silicone hydrogel materials over this short time frame.
AB - Purpose: To investigate the inflammatory response of the ocular surface with different soft contact lens (CL) replacement frequencies and materials. Methods: Twenty soft CL wearers were required to wear 3 lens types: reusable Acuvue 2 (A2), reusable Acuvue Oasys (AO), and daily disposable Acuvue Oasys (AODD), for 1 week in random sequence in 1 eye with the nonlens-wearing eye acting as a control. Three methods were used to assess the subclinical response: tear cytokine evaluation, in vivo confocal microscopy (IVCM), and impression cytology. Results: Of 13 cytokines investigated, differences were observed only for IL-12p70, which was present in greater concentrations for A2 (interocular difference 8.8 pg/mL, 95% confidence interval 5.5–12.1) and AO (8.9 [5.7–12.1]) compared with AODD (3.7 [0.6–6.8]). For IVCM, corneal presumed dendritic cell density was lower for AODD (interocular difference 1.9 [20.1 to 3.9] cells/mm 2) than for both A2 (9.3 [7.2–11.4]) and AO (10.6 [8.6–12.6]). This trend was the same for the other 5 IVCM measures evaluated. The proportion of CD45 + cells in the bulbar conjunctiva was lower for AODD (0.6 [20.3 to 1.5]%) compared with A2 (4.6 [3.7–5.6]) and AO (4.8 [3.9–5.8]). Similar findings were observed for cells in the upper lid margin. Conclusions: This work has demonstrated for the first time that daily disposable CL wear produces a minimal subclinical inflammatory response compared with no lens wear over 1 week. By contrast, this inflammatory response is upregulated with reusable lenses but appears to be similar between hydrogel and silicone hydrogel materials over this short time frame.
KW - contact lens
KW - hydrogel
KW - inflammation
KW - modality
KW - silicone hydrogel
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85077402200&partnerID=MN8TOARS
U2 - 10.1097/ICO.0000000000002192
DO - 10.1097/ICO.0000000000002192
M3 - Article
C2 - 31725697
SN - 0277-3740
VL - 39
SP - 146
EP - 154
JO - Cornea
JF - Cornea
IS - 2
ER -