Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus

Hugh Mccann; J. C. Murrieta-Lee; C. J D Pomfrett; P. C W Beatty; N. Polydorides; C. B. Mussel; R. C. Waterfall; H. McCann

doi:10.1109/IEMBS.2004.1403414

Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus

Hugh Mccann, J. C. Murrieta-Lee, C. J D Pomfrett, P. C W Beatty, N. Polydorides, C. B. Mussel, R. C. Waterfall, H. McCann

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Abstract

A pilot study has investigated the feasibility of imaging human brain function using an Electrical Impedance Tomography (EIT) system time-locked to an Evoked Response (ER) system. A sixteen-electrode planar EIT configuration was used with polar current injection. We report here measurements on two volunteer patients who were fully awake in all tests. Reference data (with no applied stimulus) yield EIT nearest-neighbour voltage differences over the range 5-28mV. In comparison with forward calculations [1], these data suggest a value of skull conductivity of the order of 0.05 S/m. Visual and Auditory stimuli were applied as single discrete events to evoke neural responses (VER and AER respectively). In each case, EIT data acquisition commenced at a time between 70 and 740ms later, taking 308ms to complete. Average values of voltage pair data over many frames are presented here, with the emphasis on the VER data. When comparing data taken under stimulus conditions against the reference data, voltage differences of up to approximately 3 mV are observed in both AER and VER cases. We attribute these voltage changes to synaptic activity. Preliminary reconstructed images of conductivity are discussed.

Original language	English
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings\|Annu Int Conf IEEE Eng Med Biol Proc
Pages	1317-1320
Number of pages	3
Volume	26
DOIs	https://doi.org/10.1109/IEMBS.2004.1403414
Publication status	Published - 2004
Event	Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA Duration: 1 Jul 2004 → …

Conference

Conference	Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
City	San Francisco, CA
Period	1/07/04 → …

Keywords

Brain
Conductivity
Electrical
Fast
Function
Imaging
Impedance
Scalp
Skull
Tomography

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10.1109/IEMBS.2004.1403414

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Mccann, H., Murrieta-Lee, J. C., Pomfrett, C. J. D., Beatty, P. C. W., Polydorides, N., Mussel, C. B., Waterfall, R. C., & McCann, H. (2004). Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|Annu Int Conf IEEE Eng Med Biol Proc (Vol. 26, pp. 1317-1320) https://doi.org/10.1109/IEMBS.2004.1403414

@inproceedings{392358df30cb4b0c9bd59c7708f07841,

title = "Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus",

abstract = "A pilot study has investigated the feasibility of imaging human brain function using an Electrical Impedance Tomography (EIT) system time-locked to an Evoked Response (ER) system. A sixteen-electrode planar EIT configuration was used with polar current injection. We report here measurements on two volunteer patients who were fully awake in all tests. Reference data (with no applied stimulus) yield EIT nearest-neighbour voltage differences over the range 5-28mV. In comparison with forward calculations [1], these data suggest a value of skull conductivity of the order of 0.05 S/m. Visual and Auditory stimuli were applied as single discrete events to evoke neural responses (VER and AER respectively). In each case, EIT data acquisition commenced at a time between 70 and 740ms later, taking 308ms to complete. Average values of voltage pair data over many frames are presented here, with the emphasis on the VER data. When comparing data taken under stimulus conditions against the reference data, voltage differences of up to approximately 3 mV are observed in both AER and VER cases. We attribute these voltage changes to synaptic activity. Preliminary reconstructed images of conductivity are discussed.",

keywords = "Brain, Conductivity, Electrical, Fast, Function, Imaging, Impedance, Scalp, Skull, Tomography",

author = "Hugh Mccann and Murrieta-Lee, {J. C.} and Pomfrett, {C. J D} and Beatty, {P. C W} and N. Polydorides and Mussel, {C. B.} and Waterfall, {R. C.} and H. McCann",

year = "2004",

doi = "10.1109/IEMBS.2004.1403414",

language = "English",

volume = "26",

pages = "1317--1320",

booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|Annu Int Conf IEEE Eng Med Biol Proc",

note = "Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 ; Conference date: 01-07-2004",

}

Mccann, H, Murrieta-Lee, JC, Pomfrett, CJD, Beatty, PCW, Polydorides, N, Mussel, CB, Waterfall, RC & McCann, H 2004, Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|Annu Int Conf IEEE Eng Med Biol Proc. vol. 26, pp. 1317-1320, Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004, San Francisco, CA, 1/07/04. https://doi.org/10.1109/IEMBS.2004.1403414

Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus. / Mccann, Hugh; Murrieta-Lee, J. C.; Pomfrett, C. J D et al.
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|Annu Int Conf IEEE Eng Med Biol Proc. Vol. 26 2004. p. 1317-1320.

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus

AU - Mccann, Hugh

AU - Murrieta-Lee, J. C.

AU - Pomfrett, C. J D

AU - Beatty, P. C W

AU - Polydorides, N.

AU - Mussel, C. B.

AU - Waterfall, R. C.

AU - McCann, H.

PY - 2004

Y1 - 2004

N2 - A pilot study has investigated the feasibility of imaging human brain function using an Electrical Impedance Tomography (EIT) system time-locked to an Evoked Response (ER) system. A sixteen-electrode planar EIT configuration was used with polar current injection. We report here measurements on two volunteer patients who were fully awake in all tests. Reference data (with no applied stimulus) yield EIT nearest-neighbour voltage differences over the range 5-28mV. In comparison with forward calculations [1], these data suggest a value of skull conductivity of the order of 0.05 S/m. Visual and Auditory stimuli were applied as single discrete events to evoke neural responses (VER and AER respectively). In each case, EIT data acquisition commenced at a time between 70 and 740ms later, taking 308ms to complete. Average values of voltage pair data over many frames are presented here, with the emphasis on the VER data. When comparing data taken under stimulus conditions against the reference data, voltage differences of up to approximately 3 mV are observed in both AER and VER cases. We attribute these voltage changes to synaptic activity. Preliminary reconstructed images of conductivity are discussed.

AB - A pilot study has investigated the feasibility of imaging human brain function using an Electrical Impedance Tomography (EIT) system time-locked to an Evoked Response (ER) system. A sixteen-electrode planar EIT configuration was used with polar current injection. We report here measurements on two volunteer patients who were fully awake in all tests. Reference data (with no applied stimulus) yield EIT nearest-neighbour voltage differences over the range 5-28mV. In comparison with forward calculations [1], these data suggest a value of skull conductivity of the order of 0.05 S/m. Visual and Auditory stimuli were applied as single discrete events to evoke neural responses (VER and AER respectively). In each case, EIT data acquisition commenced at a time between 70 and 740ms later, taking 308ms to complete. Average values of voltage pair data over many frames are presented here, with the emphasis on the VER data. When comparing data taken under stimulus conditions against the reference data, voltage differences of up to approximately 3 mV are observed in both AER and VER cases. We attribute these voltage changes to synaptic activity. Preliminary reconstructed images of conductivity are discussed.

KW - Brain

KW - Conductivity

KW - Electrical

KW - Fast

KW - Function

KW - Imaging

KW - Impedance

KW - Scalp

KW - Skull

KW - Tomography

U2 - 10.1109/IEMBS.2004.1403414

DO - 10.1109/IEMBS.2004.1403414

M3 - Conference contribution

VL - 26

SP - 1317

EP - 1320

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|Annu Int Conf IEEE Eng Med Biol Proc

T2 - Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004

Y2 - 1 July 2004

ER -

Sub-second observations of EIT voltage changes on the human scalp due to brain stimulus

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