SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY

John Caldwell; Faria Da Fonseca McHardy, Tatiana; Arthur Luke, Richard, William; Stanley Matusiak, Zbigniew; Andrew Leach; James Morris, Jeffrey; John Woodhead, Steven; Martyn Frederickson; Christopher Hamlett; James Woodhead, Andrew; Leendert Verdonk, Marinus; Fiona Sore, Hannah; Winter Walker, David; Peter Blurton; Ian Collins; Ming Cheung, Kwai

SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY

John Caldwell (Inventor), Faria Da Fonseca McHardy, Tatiana (Inventor), Arthur Luke, Richard, William (Inventor), Stanley Matusiak, Zbigniew (Inventor), Andrew Leach (Inventor), James Morris, Jeffrey (Inventor), John Woodhead, Steven (Inventor), Martyn Frederickson (Inventor), Christopher Hamlett (Inventor), James Woodhead, Andrew (Inventor), Leendert Verdonk, Marinus (Inventor), Fiona Sore, Hannah (Inventor), Winter Walker, David (Inventor), Peter Blurton (Inventor), Ian Collins (Inventor), Ming Cheung, Kwai (Inventor)

Pharmacy

Research output: Patent

Abstract

The invention provides PKA and PKB kinase-inhibiting compounds of the formula (I); or salts, solvates, tautomers or N-oxides thereof, wherein E is a five membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from O, N and S provided that no more than 1 heteroatom may be other than N; q and r are each is 0 or 1; provided that q+r is 1 or 2; T is N or a group CR; J-J is N=C(R), (R)C=N, (R)N- C(O), (R)2C-C(O), N=N or (R)C=C(R); Q is a bond or a saturated C1-3 hydrocarbon linker group optionally substituted by fluorine and hydroxy; G is NRR, CN or OH; m and n are each 0 or 1, provided that m+n is 1 or 2, and provided also that m or n are each 0 when the adjacent ring member of ring E is S or O; R and R are the same or different and each is hydrogen or a substituent R; or R and R together with the carbon atoms or heteroatoms to which they are attached form a 5 or 6-membered aryl or heteroaryl ring, wherein the aryl or heteroaryl rings are optionally substituted by one or more substituents R; and R, R, R, R, R, R, R, and R are as defined in the claims.

Original language	English
Patent number	WO2008075109
IPC	C07D 519/ 00 A I
Priority date	25/10/07
Publication status	Published - 26 Jun 2008

Cite this

Caldwell, J., Da Fonseca McHardy, Tatiana, F., Luke, Richard, William, A., Matusiak, Zbigniew, S., Leach, A., Morris, Jeffrey, J., Woodhead, Steven, J., Frederickson, M., Hamlett, C., Woodhead, Andrew, J., Verdonk, Marinus, L., Sore, Hannah, F., Walker, David, W., Blurton, P., Collins, I., & Cheung, Kwai, M. (2008). SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY. (Patent No. WO2008075109).

@misc{d34ff37dbecf4d849f642ff84bf78787,

title = "SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY",

abstract = "The invention provides PKA and PKB kinase-inhibiting compounds of the formula (I); or salts, solvates, tautomers or N-oxides thereof, wherein E is a five membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from O, N and S provided that no more than 1 heteroatom may be other than N; q and r are each is 0 or 1; provided that q+r is 1 or 2; T is N or a group CR; J-J is N=C(R), (R)C=N, (R)N- C(O), (R)2C-C(O), N=N or (R)C=C(R); Q is a bond or a saturated C1-3 hydrocarbon linker group optionally substituted by fluorine and hydroxy; G is NRR, CN or OH; m and n are each 0 or 1, provided that m+n is 1 or 2, and provided also that m or n are each 0 when the adjacent ring member of ring E is S or O; R and R are the same or different and each is hydrogen or a substituent R; or R and R together with the carbon atoms or heteroatoms to which they are attached form a 5 or 6-membered aryl or heteroaryl ring, wherein the aryl or heteroaryl rings are optionally substituted by one or more substituents R; and R, R, R, R, R, R, R, and R are as defined in the claims.",

author = "John Caldwell and {Da Fonseca McHardy, Tatiana}, Faria and {Luke, Richard, William}, Arthur and {Matusiak, Zbigniew}, Stanley and Andrew Leach and {Morris, Jeffrey}, James and {Woodhead, Steven}, John and Martyn Frederickson and Christopher Hamlett and {Woodhead, Andrew}, James and {Verdonk, Marinus}, Leendert and {Sore, Hannah}, Fiona and {Walker, David}, Winter and Peter Blurton and Ian Collins and {Cheung, Kwai}, Ming",

year = "2008",

month = jun,

day = "26",

language = "English",

type = "Patent",

note = "WO2008075109; C07D 519/ 00 A I",

}

Caldwell, J, Da Fonseca McHardy, Tatiana, F, Luke, Richard, William, A, Matusiak, Zbigniew, S, Leach, A, Morris, Jeffrey, J, Woodhead, Steven, J, Frederickson, M, Hamlett, C, Woodhead, Andrew, J, Verdonk, Marinus, L, Sore, Hannah, F, Walker, David, W, Blurton, P, Collins, I & Cheung, Kwai, M Jun. 26 2008, SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY, Patent No. WO2008075109.

TY - PAT

T1 - SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY

AU - Caldwell, John

AU - Da Fonseca McHardy, Tatiana, Faria

AU - Luke, Richard, William, Arthur

AU - Matusiak, Zbigniew, Stanley

AU - Leach, Andrew

AU - Morris, Jeffrey, James

AU - Woodhead, Steven, John

AU - Frederickson, Martyn

AU - Hamlett, Christopher

AU - Woodhead, Andrew, James

AU - Verdonk, Marinus, Leendert

AU - Sore, Hannah, Fiona

AU - Walker, David, Winter

AU - Blurton, Peter

AU - Collins, Ian

AU - Cheung, Kwai, Ming

PY - 2008/6/26

Y1 - 2008/6/26

N2 - The invention provides PKA and PKB kinase-inhibiting compounds of the formula (I); or salts, solvates, tautomers or N-oxides thereof, wherein E is a five membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from O, N and S provided that no more than 1 heteroatom may be other than N; q and r are each is 0 or 1; provided that q+r is 1 or 2; T is N or a group CR; J-J is N=C(R), (R)C=N, (R)N- C(O), (R)2C-C(O), N=N or (R)C=C(R); Q is a bond or a saturated C1-3 hydrocarbon linker group optionally substituted by fluorine and hydroxy; G is NRR, CN or OH; m and n are each 0 or 1, provided that m+n is 1 or 2, and provided also that m or n are each 0 when the adjacent ring member of ring E is S or O; R and R are the same or different and each is hydrogen or a substituent R; or R and R together with the carbon atoms or heteroatoms to which they are attached form a 5 or 6-membered aryl or heteroaryl ring, wherein the aryl or heteroaryl rings are optionally substituted by one or more substituents R; and R, R, R, R, R, R, R, and R are as defined in the claims.

AB - The invention provides PKA and PKB kinase-inhibiting compounds of the formula (I); or salts, solvates, tautomers or N-oxides thereof, wherein E is a five membered heteroaryl ring containing 1, 2, 3 or 4 heteroatoms selected from O, N and S provided that no more than 1 heteroatom may be other than N; q and r are each is 0 or 1; provided that q+r is 1 or 2; T is N or a group CR; J-J is N=C(R), (R)C=N, (R)N- C(O), (R)2C-C(O), N=N or (R)C=C(R); Q is a bond or a saturated C1-3 hydrocarbon linker group optionally substituted by fluorine and hydroxy; G is NRR, CN or OH; m and n are each 0 or 1, provided that m+n is 1 or 2, and provided also that m or n are each 0 when the adjacent ring member of ring E is S or O; R and R are the same or different and each is hydrogen or a substituent R; or R and R together with the carbon atoms or heteroatoms to which they are attached form a 5 or 6-membered aryl or heteroaryl ring, wherein the aryl or heteroaryl rings are optionally substituted by one or more substituents R; and R, R, R, R, R, R, R, and R are as defined in the claims.

M3 - Patent

M1 - WO2008075109

ER -

SUBSTITUTED PIPERIDINES HAVING PROTEIN KINASE INHIBITING ACTIVITY

Abstract

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