Substrate-free multi-cellular aggregates of human gingival fibroblasts - Fabrication, biomechanics and significance for tissue regeneration

Andreas Undisz, Erik Geuther, Andrea Völpel, David C. Watts, Markus Rettenmayr, Bernd W. Sigusch

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objectives: We fabricate multi-cellular aggregates of human gingival fibroblasts (hGFs) using a novel in vivo method that omits supportive flexible substrates. On the basis of the multi-cellular aggregates, constructive and destructive effects of mechanical stimulation are investigated. Methods: hGFs were seeded onto aligned glass slides (one fixed, one mobile) with an initial gap
    Original languageEnglish
    Pages (from-to)332-338
    Number of pages6
    JournalDental Materials
    Volume29
    Issue number3
    DOIs
    Publication statusPublished - Mar 2013

    Keywords

    • Biomechanics
    • Cell culture
    • Multi-cellular aggregates
    • Periodontitis
    • Substrate-free
    • Tissue regeneration

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