Substrate-free multi-cellular aggregates of human gingival fibroblasts - Fabrication, biomechanics and significance for tissue regeneration

Andreas Undisz; Erik Geuther; Andrea Völpel; David C. Watts; Markus Rettenmayr; Bernd W. Sigusch

doi:10.1016/j.dental.2012.12.001

Substrate-free multi-cellular aggregates of human gingival fibroblasts - Fabrication, biomechanics and significance for tissue regeneration

Andreas Undisz, Erik Geuther, Andrea Völpel, David C. Watts, Markus Rettenmayr, Bernd W. Sigusch

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: We fabricate multi-cellular aggregates of human gingival fibroblasts (hGFs) using a novel in vivo method that omits supportive flexible substrates. On the basis of the multi-cellular aggregates, constructive and destructive effects of mechanical stimulation are investigated. Methods: hGFs were seeded onto aligned glass slides (one fixed, one mobile) with an initial gap

Original language	English
Pages (from-to)	332-338
Number of pages	6
Journal	Dental Materials
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.dental.2012.12.001
Publication status	Published - Mar 2013

Keywords

Biomechanics
Cell culture
Multi-cellular aggregates
Periodontitis
Substrate-free
Tissue regeneration

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10.1016/j.dental.2012.12.001

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title = "Substrate-free multi-cellular aggregates of human gingival fibroblasts - Fabrication, biomechanics and significance for tissue regeneration",

abstract = "Objectives: We fabricate multi-cellular aggregates of human gingival fibroblasts (hGFs) using a novel in vivo method that omits supportive flexible substrates. On the basis of the multi-cellular aggregates, constructive and destructive effects of mechanical stimulation are investigated. Methods: hGFs were seeded onto aligned glass slides (one fixed, one mobile) with an initial gap",

keywords = "Biomechanics, Cell culture, Multi-cellular aggregates, Periodontitis, Substrate-free, Tissue regeneration",

author = "Andreas Undisz and Erik Geuther and Andrea V{\"o}lpel and Watts, {David C.} and Markus Rettenmayr and Sigusch, {Bernd W.}",

year = "2013",

month = mar,

doi = "10.1016/j.dental.2012.12.001",

language = "English",

volume = "29",

pages = "332--338",

journal = "Dental Materials",

issn = "0109-5641",

publisher = "Elsevier BV",

number = "3",

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T1 - Substrate-free multi-cellular aggregates of human gingival fibroblasts - Fabrication, biomechanics and significance for tissue regeneration

AU - Undisz, Andreas

AU - Geuther, Erik

AU - Völpel, Andrea

AU - Watts, David C.

AU - Rettenmayr, Markus

AU - Sigusch, Bernd W.

PY - 2013/3

Y1 - 2013/3

N2 - Objectives: We fabricate multi-cellular aggregates of human gingival fibroblasts (hGFs) using a novel in vivo method that omits supportive flexible substrates. On the basis of the multi-cellular aggregates, constructive and destructive effects of mechanical stimulation are investigated. Methods: hGFs were seeded onto aligned glass slides (one fixed, one mobile) with an initial gap

AB - Objectives: We fabricate multi-cellular aggregates of human gingival fibroblasts (hGFs) using a novel in vivo method that omits supportive flexible substrates. On the basis of the multi-cellular aggregates, constructive and destructive effects of mechanical stimulation are investigated. Methods: hGFs were seeded onto aligned glass slides (one fixed, one mobile) with an initial gap

KW - Biomechanics

KW - Cell culture

KW - Multi-cellular aggregates

KW - Periodontitis

KW - Substrate-free

KW - Tissue regeneration

U2 - 10.1016/j.dental.2012.12.001

DO - 10.1016/j.dental.2012.12.001

M3 - Article

VL - 29

SP - 332

EP - 338

JO - Dental Materials

JF - Dental Materials

SN - 0109-5641

IS - 3

ER -

Substrate-free multi-cellular aggregates of human gingival fibroblasts - Fabrication, biomechanics and significance for tissue regeneration

Abstract

Keywords

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