Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

J. R. Kerr; V. S. Cunniffe; P. Kelleher; R. M. Bernstein; I. N. Bruce

doi:10.1086/374666

Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

J. R. Kerr, V. S. Cunniffe, P. Kelleher, R. M. Bernstein, I. N. Bruce

Research output: Contribution to journal › Article › peer-review

Abstract

Three cases of chronic fatigue syndrome (CFS) that followed acute parvovirus B19 infection were treated with a 5-day course of intravenous immunoglobulin (IVIG; 400 mg/kg per day), the only specific treatment for parvovirus B19 infection. We examined the influence of IVIG treatment on the production of cytokines and chemokines in individuals with CFS due to parvovirus B19. IVIG therapy led to clearance of parvovirus B19 viremia, resolution of symptoms, and improvement in physical and functional ability in all patients, as well as resolution of cytokine dysregulation.

Original language	English
Pages (from-to)	e100-106
Journal	Clinical Infectious Diseases
Volume	36
Issue number	9
DOIs	https://doi.org/10.1086/374666
Publication status	Published - 1 May 2003

Keywords

Adult
Case Report
Cytokines
Fatigue
Fatigue Syndrome,Chronic
Female
Human
Immunoglobulins,Intravenous
immunology
Male
microbiology
Middle Age
Parvoviridae Infections
Parvovirus B19,Human
Support,Non-U.S.Gov't
Syndrome
therapeutic use
therapy
Treatment Outcome
Viremia
virology

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title = "Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.",

abstract = "Three cases of chronic fatigue syndrome (CFS) that followed acute parvovirus B19 infection were treated with a 5-day course of intravenous immunoglobulin (IVIG; 400 mg/kg per day), the only specific treatment for parvovirus B19 infection. We examined the influence of IVIG treatment on the production of cytokines and chemokines in individuals with CFS due to parvovirus B19. IVIG therapy led to clearance of parvovirus B19 viremia, resolution of symptoms, and improvement in physical and functional ability in all patients, as well as resolution of cytokine dysregulation.",

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AU - Cunniffe, V. S.

AU - Kelleher, P.

AU - Bernstein, R. M.

AU - Bruce, I. N.

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AB - Three cases of chronic fatigue syndrome (CFS) that followed acute parvovirus B19 infection were treated with a 5-day course of intravenous immunoglobulin (IVIG; 400 mg/kg per day), the only specific treatment for parvovirus B19 infection. We examined the influence of IVIG treatment on the production of cytokines and chemokines in individuals with CFS due to parvovirus B19. IVIG therapy led to clearance of parvovirus B19 viremia, resolution of symptoms, and improvement in physical and functional ability in all patients, as well as resolution of cytokine dysregulation.

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KW - Case Report

KW - Cytokines

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KW - Fatigue Syndrome,Chronic

KW - Female

KW - Human

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KW - immunology

KW - Male

KW - microbiology

KW - Middle Age

KW - Parvoviridae Infections

KW - Parvovirus B19,Human

KW - Support,Non-U.S.Gov't

KW - Syndrome

KW - therapeutic use

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SP - e100-106

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 9

ER -

Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.

Abstract

Keywords

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