Abstract
| Original language | English |
|---|---|
| Journal | Journal of Affective Disorders |
| Volume | 151 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Oct 2013 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- Cohort studies
- Huntington's disease
- Psychopathology
- Psychopharmacology
- Suicidal ideation
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}
In: Journal of Affective Disorders, Vol. 151, No. 1, 10.2013.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Suicidal ideation in a European Huntington's disease population.
AU - Hubers, Anna A M
AU - Bernhard Landwehrmeyer, G
AU - van der Mast, Rose C
AU - Giltay, Erik J
A2 - Bachoud-Lévi, A-C
A2 - Bentivoglio, A R
A2 - Biunno, I
A2 - Bonelli, R M
A2 - Burgunder, J-M
A2 - Dunnett, S B
A2 - Ferreira, J J
A2 - Handley, O J
A2 - Heiberg, A
A2 - llmann, T I
A2 - Landwehrmeyer, G B
A2 - Levey, J
A2 - Ramos-Arroyo, Maria A
A2 - Nielsen, J E
A2 - ProKoivisto, S
A2 - Päivärinta, M
A2 - Roos, R A C
A2 - Rojo Sebastián, A
A2 - Tabrizi, S J
A2 - Vandenberghe, W
A2 - Verellen- Dumoulin, C
A2 - Zaremba, J
A2 - Uhrova, T
A2 - Wahlström, J
A2 - Barth, Katrin
A2 - Correia-Guedes, Leonor
A2 - Finisterra, Ana Maria
A2 - Garde, Monica Bascuñana
A2 - Bos, Reineke
A2 - Betz, Sabrina
A2 - Callaghan, Jenny
A2 - Fullam, Ruth
A2 - Ecker, Daniel
A2 - Nielsen, Mette Gilling
A2 - Hvalstedt, Carina
A2 - Held, Christine
A2 - Koppers, Kerstin
A2 - Laurà, Matilde
A2 - Horta, Saul Martinez
A2 - Descals, Asunción Martínez
A2 - Mestre, Tiago
A2 - Minster, Sara
A2 - Monza, Daniela
A2 - Mütze, Lisanne
A2 - Oehmen, Martin
A2 - Townhill, Jenny
A2 - Orth, Michael
A2 - Padieu, Helene
A2 - Paterski, Laurent
A2 - Peppa, Nadia
A2 - Roedig, Verena
A2 - Rialland, Amandine
A2 - Røren, Niini
A2 - Šašinková, Pavla
A2 - Seliverstov, Yury
A2 - Cubillo, Patricia Trigo
A2 - Walsem, Marleen Rvan
A2 - Wright, Abigail
A2 - da Silva, Wildson Vieira
A2 - Witjes-Ané, Marie-Noelle
A2 - Yudina, Elizaveta
A2 - Zielonka, Daniel
A2 - Zielonka, Eugeniusz
A2 - Zinzi, Paola
A2 - Bonelli, Raphael M
A2 - Herranhof, Brigitte
A2 - Holl, Anna
A2 - Kapfhammer, Hans-Peter
A2 - Koppitz, Michael
A2 - Magnet, Markus
A2 - Otti, Daniela
A2 - Painold, Annamaria
A2 - Reisinger, Karin
A2 - Scheibl, Monika
A2 - Hecht, Karen
A2 - Lilek, Sabine
A2 - Müller, Nicole
A2 - Schöggl, Helmut
A2 - Ullah, Jasmin
A2 - Brugger, Florian
A2 - Hepperger, Caroline
A2 - Hotter, Anna
A2 - Seppi, Klaus
A2 - Wenning, Gregor
A2 - Buratti, Lisa
A2 - Hametner, Eva-Maria
A2 - Holas, Christiane
A2 - Hussl, Anna
A2 - Poewe, Werner
A2 - Braunwarth, Eva-Maria
A2 - Sprenger, Fabienne
A2 - Müller, Christoph
A2 - Lilek, Stefan
A2 - Sinadinosa, Daniela
A2 - Walleczek, Anna Maria
A2 - Ladurner, Gunther
A2 - Staffen, Wolfgang
A2 - Flamez, Anja
A2 - Morez, V
A2 - de Raedt, Sylvie
A2 - Boogaerts, Andrea
A2 - Vandenberghe, Wim
A2 - van Reijen, Dimphna
A2 - Klempíř, Jiří
A2 - Majerová, Veronika
A2 - Roth, Jan
A2 - Hartikainen, Päivi
A2 - Hiivola, Heli
A2 - Martikainen, Kirsti
A2 - Tuuha, Katri
A2 - Ignatius, Jaakko
A2 - Kärppä, Mikko
A2 - Åman, Jaana
A2 - Mustonen, Aki
A2 - Kajula, Outi
A2 - Santala, Maire
A2 - Allain, Philippe
A2 - Guérid, Marie-Anne
A2 - Gohier, Bénédicte
A2 - Olivier, Audrey
A2 - Prundean, Adriana
A2 - Scherer- Gagou, Clarisse
A2 - Verny, Christophe
A2 - Bost, Marie
A2 - Babiloni, Blandine
A2 - Debruxelles, Sabrina
A2 - Duché, Charlotte
A2 - Goizet, Cyril
A2 - Lafoucrière, Danielle
A2 - Jameau, Laetitia
A2 - Spampinato, Umberto
A2 - De Bruycker, Christelle
A2 - Cabaret, Maryline
A2 - Carette, Anne-Sophie
A2 - Defebvre, Luc
A2 - Decorte, Eric
A2 - Delval, Arnaud
A2 - Delliaux, Marie
A2 - Destee, Alain
A2 - Dujardin, Kathy
A2 - Peter, Mireille
A2 - Plomhouse, Lucie
A2 - Sablonnière, Bernard
A2 - Simonin, Clémence
A2 - Lemaire, Marie-Hélène
A2 - Manouvrier, Sylvie
A2 - Thibault-Tanchou, Stéphanie
A2 - Vuillaume, Isabelle
A2 - Krystkowiak, Pierre
A2 - Duru, Cécile
A2 - Roussel, Martine
A2 - Wannepain, Sandrine
A2 - Berrissoul, Hassan
A2 - Bellonet, Marcellin
A2 - Courtin, Françoise
A2 - Mantaux, Béatrice
A2 - Fasquel, Véronique
A2 - Godefroy, Olivier
A2 - Azulay, Jean-Philippe
A2 - Fluchère, Frédér- ique
A2 - Delfini, Marie
A2 - Eusebio, Alexandre
A2 - Mundler, Laura
A2 - Longato, Nadine
A2 - Rudolf, Gabrielle
A2 - Steinmetz, Gisèle
A2 - Tranchant, Christine
A2 - Wagner, Caroline
A2 - Zimmermann, Marie- Agathe
A2 - Marcel, Christophe
A2 - Calvas, Fabienne
A2 - Pariente, Jérémie
A2 - Démonet, Jean-François
A2 - Cheriet, Samia
A2 - Kosinski, Christoph Michael
A2 - Milkereit, Eva
A2 - Probst, Daniela
A2 - Reetz, Kathrin
A2 - Sass, Christian
A2 - Schiefer, Johannes
A2 - Schlangen, Christiane
A2 - Werner, Cornelius J
A2 - Gelderblom, Harald
A2 - Priller, Josef
A2 - Prüß, Harald
A2 - Spruth, Eike Jakob
A2 - Andrich, Jürgen
A2 - Ellrichmann, Gisa
A2 - Hoffmann, Rainer
A2 - Kaminski, Barbara
A2 - Saft, Carsten
A2 - Stamm, Christiane
A2 - Lange, Herwig
A2 - Bosredon, Cecile
A2 - Maass, Antonia
A2 - Schmidt, Simone
A2 - Storch, Alexander
A2 - Wolz, Martin
A2 - Kohl, Zacharias
A2 - Winkler, Jürgen
A2 - Capetian, Philipp
A2 - Lambeck, Johann
A2 - Zucker, Birgit
A2 - Boelmans, Kai
A2 - Ganos, Christos
A2 - Goerendt, Ines
A2 - Hidding, Ute
A2 - Lewerenz, Jan
A2 - Münchau, Alexander
A2 - Schmalfeld, Jenny
A2 - Stubbe, Lars
A2 - Zittel, Simone
A2 - Diercks, Gabriele
A2 - Dressler, Dirk
A2 - Gorzolla, Heike
A2 - Schrader, Christoph
A2 - Tacik, Pawel
A2 - Heinicke, Walburgis
A2 - Longinus, Bernhard
A2 - Bürk, Kathrin
A2 - Möller, Jens Carsten
A2 - Rissling, Ida
A2 - Mühlau, Mark
A2 - Peinemann, Alexander
A2 - Städtler, Michael
A2 - Weindl, Adolf
A2 - Winkelmann, Juliane
A2 - Ziegler, Cornelia
A2 - Bohlen, Stefan
A2 - Hölzner, Eva
A2 - Reilmann, Ralf
A2 - Dose, Matthias
A2 - Leythaeuser, Gabriele
A2 - Marquard, Ralf
A2 - Raab, Tina
A2 - Schrenk, Caroline
A2 - Schuierer, Michele
A2 - Buck, Andrea
A2 - Connemann, Julia
A2 - Eschenbach, Carolin
A2 - Landwehrmeyer, Bernhard
A2 - Lezius, Franziska
A2 - Nepper, Solveig
A2 - Niess, Anke
A2 - Schwenk, Daniela
A2 - Süßmuth, Sigurd
A2 - Trautmann, Sonja
A2 - Weydt, Patrick
A2 - Cormio, Claudia
A2 - Sciruicchio, Vittorio
A2 - Serpino, Claudia
A2 - Tommaso, Marinade
A2 - Capellari, Sabina
A2 - Cortelli, Pietro
A2 - Gallassi, Roberto
A2 - Poda, Roberto
A2 - Rizzo, Giovanni
A2 - Scaglione, Cesa
A2 - Bertini, Elisabetta
A2 - Ghelli, Elena
A2 - Ginestroni, Andrea
A2 - Massaro, Francesca
A2 - Mechi, Claudia
A2 - Paganini, Marco
A2 - Piacentini, Silvia
A2 - Pradella, Silvia
A2 - Romoli, Anna Maria
A2 - Sorbi, Sandro
A2 - Abbruzzese, Giovanni
A2 - di Poggio, Monica Bandettini
A2 - Di Maria, Emilio
A2 - Ferrandes, Giovanna
A2 - Mandich, Paola
A2 - Marchese, Roberta
A2 - Albanese, Alberto
A2 - Di Bella, Daniela
A2 - Di Donato, Stefano
A2 - Gellera, Cinzia
A2 - Genitrini, Silvia
A2 - Mariotti, Caterina
A2 - Nanetti, Lorenzo
A2 - Paridi, Dominga
A2 - Soliveri, Paola
A2 - Tomasello, Chiara
A2 - De Michele, Giuseppe
A2 - Di Maio, Luigi
A2 - Salvatore, Elena
A2 - Rinaldi, Carlo
A2 - Rossi, Fabiana
A2 - Massarelli, Marco
A2 - Roca, Alessandro
A2 - Ammendola, Sarah
A2 - Russo, Cinzia Valeria
A2 - Squitieri, Ferdinando
A2 - Elifani, Francesca
A2 - Maglione, Vittorio
A2 - Di Pardo, Alba
A2 - Alberti, Silvia
A2 - Griguoli, Annamaria
A2 - Amico, Enrico
A2 - Martino, Tiziana
A2 - Petrollini, Martina
A2 - Bentivoglio, Anna Rita
A2 - Catalli, Claudio
A2 - Di Giacopo, Raffaella
A2 - Fasano, Alfonso
A2 - Frontali, Marina
A2 - Guidubaldi, Arianna
A2 - Ialongo, Tamara
A2 - Jacopini, Gioia
A2 - Loria, Giovanna
A2 - Piano, Carla
A2 - Chiara, Piccininni
A2 - Quaranta, Davide
A2 - Romano, Silvia
A2 - Soleti, Francesco
A2 - Spadaro, Maria
A2 - van Hout, Monique S E
A2 - van Vugt, Jeroen P P
A2 - Weert, A Maritde
A2 - Bolwijn, J J W
A2 - Dekker, M
A2 - Leenders, K L
A2 - Kremer, H P H
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A2 - van den Bogaard, Simon J A
A2 - Roos, Raymund A C
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A2 - van Duijn, Erik
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A2 - Hauge, Erik
A2 - Tyvoll, Hilde
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A2 - Bjørgo, Kathrine
A2 - Fannemel, Madeleine
A2 - Gørvell, Per
A2 - Lorentzen, Eirin
A2 - Koivisto, Susana Pro
A2 - Retterstøl, Lars
A2 - Overland, Torborg
A2 - Stokke, Bodil
A2 - Sando, Botne
A2 - Dziadkiewicz, Artur
A2 - Nowak, Malgorzata
A2 - Robowski, Piotr
A2 - Sitek, Emilia
A2 - Slawek, Jaroslaw
A2 - Soltan, Witold
A2 - Szinwelski, Michal
A2 - Blaszcyk, Magdalena
A2 - Boczarska-Jedynak, Magdalena
A2 - Ciach-Wysocka, Ewelina
A2 - Gorzkowska, Agnieszka
A2 - Jasinska-Myga, Barbara
A2 - Opala, Gregorz
A2 - Kłodowska-Duda, Gabriela
A2 - Stompel, Daniel
A2 - Banaszkiewicz, Krzysztof
A2 - Boćwińska, Dorota
A2 - Szczudlik, Andrzej
A2 - Rudzińska, Monika
A2 - Wójcik, Magdalena
A2 - Dec, Małgorzata
A2 - Krawczyk, Malgorzata
A2 - Jaremek, Kamila Bojakowska
A2 - Szczygieł, Elżbieta
A2 - Stenwak, Agata
A2 - ielewska, Anna Was
A2 - Bryl, Anna
A2 - Ciesielska, Anna
A2 - Klimberg, Aneta
A2 - Marcinkowski, Jerzy
A2 - Sempołowicz, Justyna
A2 - Samara, Husam
A2 - Wiśniewski, Bartłomiej
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A2 - Gogol, Anna
A2 - Kwiecinski, Hubert
A2 - Jamrozik, Zygmunt
A2 - Kaminska, Anna
A2 - Antczak, Jakub
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A2 - Richter, Przemyslaw
A2 - Rola, Rafal
A2 - Ryglewicz, Danuta
A2 - Sienkiewicz-Jarosz, Halina
A2 - Stępniak, Iwona
A2 - Witkowski, Grzegorz
A2 - Zdzienicka, Elzbieta
A2 - Zaremba, Jacek
A2 - Sułek, Anna
A2 - Krysa, Wioletta
A2 - Zieora-Jakutowicz, Karolina
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A2 - Gago, Miguel
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A2 - Guerra, Maria Rosália
A2 - Lima, Joana
A2 - Massano, João
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A2 - Garcia, Patrocinio Moreno
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A2 - Morales, Blas
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A2 - Alonso-Frech, Fernando
A2 - Perez, Maria Rabasa
A2 - Fenollar, María
A2 - García, Rocío García-Ramos
A2 - Quiroga, Purificacion Pin
A2 - Rivera, Susana Vázquez
A2 - Villanueva, Clara
A2 - Alegre, Javier
A2 - Bascuñana, Mónica
A2 - Caldentey, Juan Garcia
A2 - Ventura, Marta Fatás
A2 - Ribas, Guillermo García
A2 - Yébenes, Justo Garcíade
A2 - López-Sendón Moreno, José Luis
A2 - García Ruíz, Pedro J
A2 - Martínez-Descals, Asunción
A2 - Artiga, María José Saiz
A2 - Sánchez, Vicenta
A2 - Guerrero, Rosa
A2 - Bárcenas, Antonio Herranz
A2 - Noguera Perea, María Fuensanta
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A2 - Reinante, Gema
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A2 - Guia, Dolors Badenes
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A2 - Sebastián, Ana Rojo
A2 - Ferrer, Pilar Quiléz
A2 - Carruesco, Gemma Tome
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A2 - Calopa, Matilde
A2 - Elorza, Marina Dalmau
A2 - Díez-AjaLópez, Cristóbal
A2 - Terol, Santiago Durán-Sindreu
A2 - Robert, Misericordia Floriach
A2 - Ruíz, Belén Garzón
A2 - Casado, Ana González
A2 - Martínez, Isabel Haro
A2 - Viladrich, Celia Mareca
A2 - Càrdenas, Regina Ponsi
A2 - Roca, Elvira
A2 - Llesoy, Joan Roig
A2 - Idiago, Jesús Miguel Ruiz
A2 - Vergara, Mar Ruíz
A2 - García, Socorro Soriano
A2 - Riballo, Antonio Villa
A2 - González, Sonia González
A2 - Guisasola, Luis Menéndez
A2 - Salvador, Carlos
A2 - San Martín, Esther Suaréz
A2 - González, Mónica
A2 - Gorospe, Aranzazú
A2 - Legarda, Inés
A2 - Arques, Penelope Navas
A2 - Torres Rodríguez, María José
A2 - Vives, Barbara
A2 - Gaston, Itziar
A2 - Martinez-Jaurrieta, Maria Dolores
A2 - Manuel, Jose
A2 - Moreno, Garcia
A2 - Peña, José Chacón
A2 - Avarvarei, Luminita Dinca
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A2 - Recio, Maria Fernández
A2 - Vergé, Luis Redondo
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A2 - Cáceres, María Teresa
A2 - Mir, Pablo
A2 - Suarez, María José Lama
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A2 - Burguera, Juan Andres
A2 - Garcia, Anabel Campos
A2 - Brugada, Francisco Casterá
A2 - Martínez, Laura Martinez
A2 - Val, Javier Lópezdel
A2 - Loutfi, Ghada
A2 - Olofsson, Carina
A2 - Stattin, Eva-Lena
A2 - Westman, Laila
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A2 - lhagen, Sven E P
A2 - Paucar, Martin
A2 - Svenningsson, Per
A2 - Reza- Soltani, Tina Walldén
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A2 - Wahlström, Jan
A2 - Høsterey-Ugander, Ulrika
A2 - Fredlund, Gunnel
A2 - Constantinescu, Radu
A2 - Neleborn-Lingefjärd, Liselotte
A2 - Tedr- off, Joakim
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A2 - Winnberg, Elisabeth
A2 - Pålhagen, Sven
A2 - Svennigsson, Per
A2 - Riza-Soltani, Tina Waldèn
A2 - Sundblom, Jimmy
A2 - Johansson, Anders
A2 - Wiklund, Leif
A2 - Ekwall, Camilla
A2 - Göller, Marie-Louise
A2 - Petersén, Asa
A2 - Reimer, Jan
A2 - Widner, Hkan
A2 - Burgunder, Jean-Marc
A2 - Stebler, Yanik
A2 - Kaelin, Alain
A2 - Romero, Irene
A2 - Schüpbach, Michael
A2 - Weber, Sabine
A2 - Miedzybrodzka, Zosia
A2 - Rae, Daniela
A2 - Downie, Lorna
A2 - Simpson, Sheila
A2 - Summers, Fiona
A2 - Ure, Alexandra
A2 - Jack, Roisin
A2 - Matheson, Kirsty
A2 - Akhtar, Shahbana
A2 - Crooks, Jenny
A2 - Curtis, Adrienne
A2 - Souza, Jennyde
A2 - Rickards, Hugh
A2 - Wright, Jan
A2 - Hayward, Beverley
A2 - Sieradzan, Kasia
A2 - Barker, Roger A
A2 - O'Keefe, Deidre
A2 - Di Pietro, Anna
A2 - Fisher, Kate
A2 - Hill, Susan
A2 - Mason, Sarah
A2 - Swain, Rachel
A2 - Valle, Natalie
A2 - Guzman, [Unknown]
A2 - Bisson, Jonathan
A2 - Busse, Monica
A2 - Butcher, Cynthia
A2 - Clenaghan, Catherine
A2 - Dunnett, Stephen
A2 - Handley, Olivia
A2 - Hunt, Sarah
A2 - Hughes, Alis
A2 - Johnstone, Catherine
A2 - Jones, Lesley
A2 - Jones, Una
A2 - Khalil, Hanan
A2 - Owen, Michael
A2 - Price, Kathleen
A2 - Rose, Linda Ellison
A2 - Rosser, Anne
A2 - Porteous, Mary
A2 - Edwards, Maureen
A2 - Ho, Carrie
A2 - McGill, Marie
A2 - Pearson, Pauline
A2 - Brockie, Peter
A2 - Foster, Jillian
A2 - Johns, Nicola
A2 - McKenzie, Sue
A2 - Rothery, Jean
A2 - Thomas, Gareth
A2 - Yates, Shona
A2 - Miller, Joanne
A2 - Ritchie, Stuart
A2 - Burrows, Liz
A2 - Fletcher, Amy
A2 - Harding, Alison
A2 - Laver, Fiona
A2 - Silva, Mark
A2 - Thomson, Aileen
A2 - Rowett, Liz
A2 - Gallantrae, Deena
A2 - Longthorpe, Mandy
A2 - Markova, Ivana
A2 - Raman, Ashok
A2 - Hamer, Stephanie
A2 - Wild, Sue
A2 - Yarduiman, Pam
A2 - Chu, Carol
A2 - Kraus, Alison
A2 - Yardumian, Pam
A2 - Musgrave, Hannah
A2 - Toscano, Jean
A2 - Jamieson, Stuart
A2 - Hobson, Emma
A2 - Clayton, Carole
A2 - Dipple, Heather
A2 - Middleton, Julia
A2 - Freire-Patino, Dawn
A2 - Andrews, Thomasin
A2 - Dougherty, Andrew
A2 - Kavalier, Fred
A2 - Golding, Charlotte
A2 - Laing, Hana
A2 - Lashwood, Alison
A2 - Robertson, Dene
A2 - Ruddy, Deborah
A2 - Whaite, Anna
A2 - Santhouse, Alastair
A2 - Patton, Michael
A2 - Peterson, Maria
A2 - Rose, Sarah
A2 - Bruno, Stefania
A2 - Chu, Elvina
A2 - Doherty, Karen
A2 - Haider, Salman
A2 - Hensman, Davina
A2 - Lahiri, Nayana
A2 - Lewis, Monica
A2 - Novak, Marianne
A2 - Patel, Aakta
A2 - Robertson, Nicola
A2 - Rosser, Elisabeth
A2 - Tabrizi, Sarah
A2 - Taylor, Rachel
A2 - Warner, Thomas
A2 - Wild, Edward
A2 - Craufurd, David
A2 - Howard, Liz
A2 - Sollom, Andrea
A2 - Snowden, Julie
A2 - Thompson, Jennifer
A2 - Jones, Mary
A2 - Murphy, Helen
A2 - Trender-Gerhard, Iris
A2 - Rogers, Dawn
A2 - Bek, Judith
A2 - Oughton, Emma
A2 - Johnson, Liz
A2 - Hare, Marianne
A2 - Arran, Natalie
A2 - Verstraelen, Nichola
A2 - Partington-Jones, Lucy
A2 - Huson, Susan
A2 - Stopford, Cheryl
A2 - Westmoreland, Leann
A2 - Davidson, Jill
A2 - Morgan, Karen
A2 - Savage, Lois
A2 - Singh, Baldev
A2 - Komati, Suresh
A2 - Nemeth, Andrea H
A2 - Armstrong, Richard
A2 - Valentine, Ruth
A2 - Siuda, Gill
A2 - Harrison, David
A2 - Hughes, Max
A2 - Parkinson, Andrew
A2 - Soltysiak, Beverley
A2 - Burn, John
A2 - Coleman, Caroline
A2 - Bandmann, Oliver
A2 - Bradbury, Alyson
A2 - Gill, Paul
A2 - Fairtlough, Helen
A2 - Fillingham, Kay
A2 - Foustanos, Isabella
A2 - Kazoka, Mbombe
A2 - O'Donovan, Kirsty
A2 - Taylor, Catherine
A2 - Tidswell, Katherine
A2 - Quarrell, Oliver
PY - 2013/10
Y1 - 2013/10
N2 - BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD. METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis. RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive. LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated. CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
AB - BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD. METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis. RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive. LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated. CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
KW - Cohort studies
KW - Huntington's disease
KW - Psychopathology
KW - Psychopharmacology
KW - Suicidal ideation
U2 - 10.1016/j.jad.2013.06.001
DO - 10.1016/j.jad.2013.06.001
M3 - Article
C2 - 23876196
SN - 1573-2517
VL - 151
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 1
ER -