Abstract
Metabolic control analysis (MCA) was developed to quantify how system variables are affected by parameter variations in a system. In addition, MCA can express the global properties of a system in terms of the individual catalytic steps, using connectivity and summation theorems to link the control coefficients to the elasticity coefficients. MCA was originally developed for steady-state analysis and not all summation theorems have been derived for dynamic systems. A method to determine time-dependent flux and concentration control coefficients for dynamic systems by expressing the time domain as a function of percentage progression through any arbitrary fixed interval of time is reported. Time-dependent flux and concentration control coefficients of dynamic systems, provided that they are evaluated in this novel way, obey the same summation theorems as steady-state flux and concentration control coefficients, respectively. © The Institution of Engineering and Technology 2006.
| Original language | English |
|---|---|
| Title of host publication | IEE Proceedings: Systems Biology|IEE Proc. Syst. Biol. |
| Pages | 314-317 |
| Number of pages | 3 |
| Volume | 153 |
| DOIs | |
| Publication status | Published - Sept 2006 |
| Event | 12th Meeting of the BioThermoKinetics/International-Study-Group-for-Systems-Biology Meeting - Trakai, LITHUANIA Duration: 1 Jan 1824 → … http://<Go to ISI>://000240324600003 |
Conference
| Conference | 12th Meeting of the BioThermoKinetics/International-Study-Group-for-Systems-Biology Meeting |
|---|---|
| City | Trakai, LITHUANIA |
| Period | 1/01/24 → … |
| Internet address |