SUMO and transcriptional repression: dynamic interactions between the MAP kinase and SUMO pathways.

Shen Hsi Yang, Ellis Jaffray, Biruntha Senthinathan, Ron T. Hay, Andrew D. Sharrocks

    Research output: Contribution to journalArticlepeer-review

    Abstract

    SUMO modification of proteins is being increasingly linked with transcriptional repression. We recently demonstrated that SUMO modification also downregulates the transcriptional activity of the ETS-domain transcription factor Elk-1. However, as Elk-1 becomes activated through MAP kinase-mediated phosphorylation, the SUMO modification is lost, providing an elegant molecular switch that promotes the loss of repressive activities at the same time as permitting the recruitment of coactivator proteins. However, the mechanism by which SUMO promotes transcriptional repression remains enigmatic.
    Original languageEnglish
    Pages (from-to)528-530
    Number of pages2
    JournalCell Cycle
    Volume2
    Issue number6
    DOIs
    Publication statusPublished - Nov 2003

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