Sural nerve pathology in diabetic patients with minimal but progressive neuropathy

R. A. Malik; S. Tesfaye; P. G. Newrick; D. Walker; S. M. Rajbhandari; I. Siddique; A. K. Sharma; A. J M Boulton; R. H M King; P. K. Thomas; J. D. Ward

doi:10.1007/s00125-004-1663-5

Sural nerve pathology in diabetic patients with minimal but progressive neuropathy

R. A. Malik, S. Tesfaye, P. G. Newrick, D. Walker, S. M. Rajbhandari, I. Siddique, A. K. Sharma, A. J M Boulton, R. H M King, P. K. Thomas, J. D. Ward

Research output: Contribution to journal › Article › peer-review

Abstract

Aims/hypothesis: The early pathological features of human diabetic neuropathy are not clearly defined. Therefore we quantified nerve fibre and microvascular pathology in sural nerve biopsies from diabetic patients with minimal neuropathy. Methods: Twelve diabetic patients underwent detailed assessment of neuropathy and fascicular sural nerve biopsy at baseline, with repeat assessment of neuropathy 8.7±0.6 years later. Results: At baseline, neuropathic symptoms, neurological deficits, quantitative sensory testing, cardiac autonomic function and peripheral nerve electrophysiology showed minimal abnormality, which deteriorated at follow-up. Myelinated fibre density, fibre and axonal area, and g-ratio were normal but teased fibre studies showed paranodal abnormalities (p

Original language	English
Pages (from-to)	578-585
Number of pages	7
Journal	Diabetologia
Volume	48
Issue number	3
DOIs	https://doi.org/10.1007/s00125-004-1663-5
Publication status	Published - Mar 2005

Keywords

Demyelination
Diabetes
Microangiopathy
Nerve fibres
Neuropathy
Schwann cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Sural nerve pathology in diabetic patients with minimal but progressive neuropathy",

abstract = "Aims/hypothesis: The early pathological features of human diabetic neuropathy are not clearly defined. Therefore we quantified nerve fibre and microvascular pathology in sural nerve biopsies from diabetic patients with minimal neuropathy. Methods: Twelve diabetic patients underwent detailed assessment of neuropathy and fascicular sural nerve biopsy at baseline, with repeat assessment of neuropathy 8.7±0.6 years later. Results: At baseline, neuropathic symptoms, neurological deficits, quantitative sensory testing, cardiac autonomic function and peripheral nerve electrophysiology showed minimal abnormality, which deteriorated at follow-up. Myelinated fibre density, fibre and axonal area, and g-ratio were normal but teased fibre studies showed paranodal abnormalities (p",

keywords = "Demyelination, Diabetes, Microangiopathy, Nerve fibres, Neuropathy, Schwann cell",

author = "Malik, {R. A.} and S. Tesfaye and Newrick, {P. G.} and D. Walker and Rajbhandari, {S. M.} and I. Siddique and Sharma, {A. K.} and Boulton, {A. J M} and King, {R. H M} and Thomas, {P. K.} and Ward, {J. D.}",

year = "2005",

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doi = "10.1007/s00125-004-1663-5",

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TY - JOUR

T1 - Sural nerve pathology in diabetic patients with minimal but progressive neuropathy

AU - Malik, R. A.

AU - Tesfaye, S.

AU - Newrick, P. G.

AU - Walker, D.

AU - Rajbhandari, S. M.

AU - Siddique, I.

AU - Sharma, A. K.

AU - Boulton, A. J M

AU - King, R. H M

AU - Thomas, P. K.

AU - Ward, J. D.

PY - 2005/3

Y1 - 2005/3

N2 - Aims/hypothesis: The early pathological features of human diabetic neuropathy are not clearly defined. Therefore we quantified nerve fibre and microvascular pathology in sural nerve biopsies from diabetic patients with minimal neuropathy. Methods: Twelve diabetic patients underwent detailed assessment of neuropathy and fascicular sural nerve biopsy at baseline, with repeat assessment of neuropathy 8.7±0.6 years later. Results: At baseline, neuropathic symptoms, neurological deficits, quantitative sensory testing, cardiac autonomic function and peripheral nerve electrophysiology showed minimal abnormality, which deteriorated at follow-up. Myelinated fibre density, fibre and axonal area, and g-ratio were normal but teased fibre studies showed paranodal abnormalities (p

AB - Aims/hypothesis: The early pathological features of human diabetic neuropathy are not clearly defined. Therefore we quantified nerve fibre and microvascular pathology in sural nerve biopsies from diabetic patients with minimal neuropathy. Methods: Twelve diabetic patients underwent detailed assessment of neuropathy and fascicular sural nerve biopsy at baseline, with repeat assessment of neuropathy 8.7±0.6 years later. Results: At baseline, neuropathic symptoms, neurological deficits, quantitative sensory testing, cardiac autonomic function and peripheral nerve electrophysiology showed minimal abnormality, which deteriorated at follow-up. Myelinated fibre density, fibre and axonal area, and g-ratio were normal but teased fibre studies showed paranodal abnormalities (p

KW - Demyelination

KW - Diabetes

KW - Microangiopathy

KW - Nerve fibres

KW - Neuropathy

KW - Schwann cell

U2 - 10.1007/s00125-004-1663-5

DO - 10.1007/s00125-004-1663-5

M3 - Article

SN - 1432-0428

VL - 48

SP - 578

EP - 585

JO - Diabetologia

JF - Diabetologia

IS - 3

ER -

Sural nerve pathology in diabetic patients with minimal but progressive neuropathy

Abstract

Keywords

UN SDGs

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