Abstract
Background: Angiogenesis is a prerequisite for tumor growth and metastasis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells as a result of vascular endothelial growth factor (VEGF) stimulation. Purpose: To determine if measurement in serum of VEGF or VCAM-1 provides an accurate measure of tumor angiogenesis. Methods: VCAM-1 and VEGF were measured in the serum of women with early and advanced breast cancer by ELISA. Levels were compared to levels of VCAM-1 and VEGF in women with normal breasts and levels of the endothelial glycoprotein von Willebrand factor. Levels of VEGF and VCAM-1 in women with early breast cancer were correlated with established clinicopathological prognostic markers and intratumoral microvessel density (IMD). Results: In early breast cancer serum VCAM-1 correlated closely with the microvessel density in tumors (r=0.61, p
| Original language | English |
|---|---|
| Pages (from-to) | 334-339 |
| Number of pages | 5 |
| Journal | International Journal of Biological Markers |
| Volume | 15 |
| Issue number | 4 |
| Publication status | Published - 2000 |
Keywords
- Angiogenesis
- Breast cancer
- Vascular cell adhesion molecule-1
- Vascular endothelial growth factor
- Von Willebrand factor
