Susceptibility and outcome in MS: Associations with polymorphisms in pigmentation-related genes

J. M. Partridge, S. J M Weatherby, J. A. Woolmore, D. J. Highland, A. A. Fryer, C. L A Mann, M. D. Boggild, W. E R Ollier, R. C. Strange, C. P. Hawkins

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these genes in MS pathogenesis.
    Original languageEnglish
    Pages (from-to)2323-2325
    Number of pages2
    JournalNeurology
    Volume62
    Issue number12
    DOIs
    Publication statusPublished - 22 Jun 2004

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