Susceptibility and outcome in MS: Associations with polymorphisms in pigmentation-related genes

J. M. Partridge; S. J M Weatherby; J. A. Woolmore; D. J. Highland; A. A. Fryer; C. L A Mann; M. D. Boggild; W. E R Ollier; R. C. Strange; C. P. Hawkins

doi:10.1212/WNL.62.12.2323

Susceptibility and outcome in MS: Associations with polymorphisms in pigmentation-related genes

J. M. Partridge, S. J M Weatherby, J. A. Woolmore, D. J. Highland, A. A. Fryer, C. L A Mann, M. D. Boggild, W. E R Ollier, R. C. Strange, C. P. Hawkins

Research output: Contribution to journal › Article › peer-review

Abstract

Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these genes in MS pathogenesis.

Original language	English
Pages (from-to)	2323-2325
Number of pages	2
Journal	Neurology
Volume	62
Issue number	12
DOIs	https://doi.org/10.1212/WNL.62.12.2323
Publication status	Published - 22 Jun 2004

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title = "Susceptibility and outcome in MS: Associations with polymorphisms in pigmentation-related genes",

abstract = "Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these genes in MS pathogenesis.",

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doi = "10.1212/WNL.62.12.2323",

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T1 - Susceptibility and outcome in MS: Associations with polymorphisms in pigmentation-related genes

AU - Partridge, J. M.

AU - Weatherby, S. J M

AU - Woolmore, J. A.

AU - Highland, D. J.

AU - Fryer, A. A.

AU - Mann, C. L A

AU - Boggild, M. D.

AU - Ollier, W. E R

AU - Strange, R. C.

AU - Hawkins, C. P.

PY - 2004/6/22

Y1 - 2004/6/22

N2 - Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these genes in MS pathogenesis.

AB - Multiple sclerosis (MS) risk is determined by environment and genes. The authors investigated in 419 cases and 422 controls if polymorphism in the vitamin D receptor (VDR), melanocortin-1 receptor (MC1R), and tyrosinase (TYR) genes is linked with MS risk and outcome. VDR ff was associated with reduced (odds ratio [OR] = 0.59) and MC1R His294-encoding alleles with increased (OR = 2.21) risk. MC1R Glu84/Glu84 was linked with disability (OR = 5.65). These preliminary data suggest a role for these genes in MS pathogenesis.

UR - https://www.scopus.com/pages/publications/2942711624

U2 - 10.1212/WNL.62.12.2323

DO - 10.1212/WNL.62.12.2323

M3 - Article

SN - 0028-3878

VL - 62

SP - 2323

EP - 2325

JO - Neurology

JF - Neurology

IS - 12

ER -

Susceptibility and outcome in MS: Associations with polymorphisms in pigmentation-related genes

Abstract

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