Susceptibility to UV-A and UV-B provocation does not correlate with disease severity of polymorphic light eruption

Objective: To examine whether the ease of disease provocation by UV-A and/or UV-B radiation correlates with clinical features of polymorphic light eruption (PLE), including those indicative of disease severity. Design: Intervention study. Patients: One hundred forty-three patients with PLE. Interventions: Provocation testing with broadband UV-A and UV-B lamps. Additionally, a range of clinical characteristics of the disorder, including a 5-item PLE severity score, was assessed by questionnaire. Main Outcome Measures: Percentage of PLE rash induction by UV-A and UV-B provocation, differences between the skin types, and correlation between the results of provocation and a range of clinical characteristics of the disorder, including a 5-item PLE severity score. Results: Rash provocation was seen in 78.3% of patients after UV-A and in 46.7% after UV-B exposure. Neither UV-A nor UV-B provocation showed a significant association with the total 5-item severity score. The UV-B reactivity was associated with a high score on the severity item "number of months affected per year" (P=.04), whereas UV-A responsiveness showed a tendency for association with facial involvement (P=.06). Conclusion: The objective assessment of UV-A or UV-B susceptibility in this large group of patients showed no significant relationship with clinical disease severity. ©2007 American Medical Association. All rights reserved.