Sustained-release diclofenac potassium orally disintegrating tablet incorporating eudragit ERL/ERS: Possibility of specific diclofenac-polymer interaction

Amjad M. Qandil; Shereen M. Assaf; Enas A. Al Ani; Alaa Eldeen Yassin; Aiman A. Obaidat

doi:10.1007/s40005-013-0065-4

Sustained-release diclofenac potassium orally disintegrating tablet incorporating eudragit ERL/ERS: Possibility of specific diclofenac-polymer interaction

Amjad M. Qandil, Shereen M. Assaf, Enas A. Al Ani, Alaa Eldeen Yassin, Aiman A. Obaidat

Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Sustained-release diclofenac potassium orally disintegrating tablet (ODT) formulations have been prepared and investigated. The ODTs were prepared by incorporating diclofenac potassium (DP), as a model for negatively ionizable drugs, in microcapsules that were prepared by the solvent evaporation method from a mixture of DP and different ratios of Eudragit RS and Eudragit RL, which are positively ionized synthetic polymers. The ODTs were prepared by direct compression of mixtures containing microcapsule formula M4, crospovidone as a superdisintegrant and water soluble excipients (mannitol or lactose and sorbitol). Diclofenac potassium ODT F2, showed acceptable hardness (4.08 KP) slight friability (2.13 %) and disintegration time of 22.41 s with a sustained drug release profile. Microcapsule characterization (DSC and FT-IR) and dissolution behavior suggests the presence of specific interaction between the carboxylate group of diclofenac and the quaternary ammonium group in the polymers

Original language	English
Pages (from-to)	171-183
Number of pages	13
Journal	Journal of Pharmaceutical Investigation
Volume	43
Issue number	3
Early online date	22 Mar 2013
DOIs	https://doi.org/10.1007/s40005-013-0065-4
Publication status	Published - Jun 2013

Keywords

Diclofenac
Eudragit RL
Eudragit RS
orally disintegrating tablet
sustained-release

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10.1007/s40005-013-0065-4

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title = "Sustained-release diclofenac potassium orally disintegrating tablet incorporating eudragit ERL/ERS: Possibility of specific diclofenac-polymer interaction",

abstract = "Sustained-release diclofenac potassium orally disintegrating tablet (ODT) formulations have been prepared and investigated. The ODTs were prepared by incorporating diclofenac potassium (DP), as a model for negatively ionizable drugs, in microcapsules that were prepared by the solvent evaporation method from a mixture of DP and different ratios of Eudragit RS and Eudragit RL, which are positively ionized synthetic polymers. The ODTs were prepared by direct compression of mixtures containing microcapsule formula M4, crospovidone as a superdisintegrant and water soluble excipients (mannitol or lactose and sorbitol). Diclofenac potassium ODT F2, showed acceptable hardness (4.08 KP) slight friability (2.13 %) and disintegration time of 22.41 s with a sustained drug release profile. Microcapsule characterization (DSC and FT-IR) and dissolution behavior suggests the presence of specific interaction between the carboxylate group of diclofenac and the quaternary ammonium group in the polymers",

keywords = "Diclofenac, Eudragit RL, Eudragit RS, orally disintegrating tablet, sustained-release",

author = "Qandil, {Amjad M.} and Assaf, {Shereen M.} and {Al Ani}, {Enas A.} and Yassin, {Alaa Eldeen} and Obaidat, {Aiman A.}",

year = "2013",

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doi = "10.1007/s40005-013-0065-4",

language = "English",

volume = "43",

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AU - Assaf, Shereen M.

AU - Al Ani, Enas A.

AU - Yassin, Alaa Eldeen

AU - Obaidat, Aiman A.

PY - 2013/6

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N2 - Sustained-release diclofenac potassium orally disintegrating tablet (ODT) formulations have been prepared and investigated. The ODTs were prepared by incorporating diclofenac potassium (DP), as a model for negatively ionizable drugs, in microcapsules that were prepared by the solvent evaporation method from a mixture of DP and different ratios of Eudragit RS and Eudragit RL, which are positively ionized synthetic polymers. The ODTs were prepared by direct compression of mixtures containing microcapsule formula M4, crospovidone as a superdisintegrant and water soluble excipients (mannitol or lactose and sorbitol). Diclofenac potassium ODT F2, showed acceptable hardness (4.08 KP) slight friability (2.13 %) and disintegration time of 22.41 s with a sustained drug release profile. Microcapsule characterization (DSC and FT-IR) and dissolution behavior suggests the presence of specific interaction between the carboxylate group of diclofenac and the quaternary ammonium group in the polymers

AB - Sustained-release diclofenac potassium orally disintegrating tablet (ODT) formulations have been prepared and investigated. The ODTs were prepared by incorporating diclofenac potassium (DP), as a model for negatively ionizable drugs, in microcapsules that were prepared by the solvent evaporation method from a mixture of DP and different ratios of Eudragit RS and Eudragit RL, which are positively ionized synthetic polymers. The ODTs were prepared by direct compression of mixtures containing microcapsule formula M4, crospovidone as a superdisintegrant and water soluble excipients (mannitol or lactose and sorbitol). Diclofenac potassium ODT F2, showed acceptable hardness (4.08 KP) slight friability (2.13 %) and disintegration time of 22.41 s with a sustained drug release profile. Microcapsule characterization (DSC and FT-IR) and dissolution behavior suggests the presence of specific interaction between the carboxylate group of diclofenac and the quaternary ammonium group in the polymers

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Sustained-release diclofenac potassium orally disintegrating tablet incorporating eudragit ERL/ERS: Possibility of specific diclofenac-polymer interaction

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