Suzuki coupling of oxazoles

Emmanuel Ferrer Flegeau; Matthew E. Popkin; Michael F. Greaney

doi:10.1021/ol060591j

Suzuki coupling of oxazoles

Emmanuel Ferrer Flegeau, Matthew E. Popkin, Michael F. Greaney

Research output: Contribution to journal › Article › peer-review

Abstract

A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo- and heterodimeric 4,4-linked dioxazoles. © 2006 American Chemical Society.

Original language	English
Pages (from-to)	2495-2498
Number of pages	3
Journal	Organic Letters
Volume	8
Issue number	12
DOIs	https://doi.org/10.1021/ol060591j
Publication status	Published - 8 Jun 2006

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title = "Suzuki coupling of oxazoles",

abstract = "A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo- and heterodimeric 4,4-linked dioxazoles. {\textcopyright} 2006 American Chemical Society.",

author = "Flegeau, {Emmanuel Ferrer} and Popkin, {Matthew E.} and Greaney, {Michael F.}",

note = "CAPLUS AN 2006:451120(Journal)",

year = "2006",

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doi = "10.1021/ol060591j",

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journal = "Organic Letters",

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T1 - Suzuki coupling of oxazoles

AU - Flegeau, Emmanuel Ferrer

AU - Popkin, Matthew E.

AU - Greaney, Michael F.

N1 - CAPLUS AN 2006:451120(Journal)

PY - 2006/6/8

Y1 - 2006/6/8

N2 - A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo- and heterodimeric 4,4-linked dioxazoles. © 2006 American Chemical Society.

AB - A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo- and heterodimeric 4,4-linked dioxazoles. © 2006 American Chemical Society.

U2 - 10.1021/ol060591j

DO - 10.1021/ol060591j

M3 - Article

SN - 1523-7052

VL - 8

SP - 2495

EP - 2498

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Suzuki coupling of oxazoles

Abstract

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