Swainsonine: a new antineoplastic immunomodulator

S Mohla; M J Humphries; S L White; K Matsumoto; S A Newton; C C Sampson; D Bowen; K Olden

Swainsonine: a new antineoplastic immunomodulator

S Mohla, M J Humphries, S L White, K Matsumoto, S A Newton, C C Sampson, D Bowen, K Olden

Division of Cell Matrix Biology & Regenerative Medicine (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins. The unique ability of swainsonine to exhibit antimetastatic, anti-proliferative, and immunomodulatory activity imparts this drug a promising future in cancer therapy.

Original language	English
Pages (from-to)	1049-56
Number of pages	8
Journal	Journal of the National Medical Association
Volume	81
Issue number	10
Publication status	Published - Oct 1989

Keywords

Adjuvants, Immunologic
Alkaloids
Animals
Antineoplastic Agents
Breast Neoplasms
Cell Line, Transformed
Cell Membrane
Humans
Mice
Mice, Inbred C57BL
Neoplasm Metastasis
Oligosaccharides
Swainsonine

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title = "Swainsonine: a new antineoplastic immunomodulator",

abstract = "Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins. The unique ability of swainsonine to exhibit antimetastatic, anti-proliferative, and immunomodulatory activity imparts this drug a promising future in cancer therapy.",

keywords = "Adjuvants, Immunologic, Alkaloids, Animals, Antineoplastic Agents, Breast Neoplasms, Cell Line, Transformed, Cell Membrane, Humans, Mice, Mice, Inbred C57BL, Neoplasm Metastasis, Oligosaccharides, Swainsonine",

author = "S Mohla and Humphries, {M J} and White, {S L} and K Matsumoto and Newton, {S A} and Sampson, {C C} and D Bowen and K Olden",

year = "1989",

month = oct,

language = "English",

volume = "81",

pages = "1049--56",

journal = "Journal of the National Medical Association",

issn = "1943-4693",

publisher = "National Medical Association",

number = "10",

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TY - JOUR

T1 - Swainsonine

T2 - a new antineoplastic immunomodulator

AU - Mohla, S

AU - Humphries, M J

AU - White, S L

AU - Matsumoto, K

AU - Newton, S A

AU - Sampson, C C

AU - Bowen, D

AU - Olden, K

PY - 1989/10

Y1 - 1989/10

N2 - Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins. The unique ability of swainsonine to exhibit antimetastatic, anti-proliferative, and immunomodulatory activity imparts this drug a promising future in cancer therapy.

AB - Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins. The unique ability of swainsonine to exhibit antimetastatic, anti-proliferative, and immunomodulatory activity imparts this drug a promising future in cancer therapy.

KW - Adjuvants, Immunologic

KW - Alkaloids

KW - Animals

KW - Antineoplastic Agents

KW - Breast Neoplasms

KW - Cell Line, Transformed

KW - Cell Membrane

KW - Humans

KW - Mice

KW - Mice, Inbred C57BL

KW - Neoplasm Metastasis

KW - Oligosaccharides

KW - Swainsonine

M3 - Article

C2 - 2509720

SN - 1943-4693

VL - 81

SP - 1049

EP - 1056

JO - Journal of the National Medical Association

JF - Journal of the National Medical Association

IS - 10

ER -

Swainsonine: a new antineoplastic immunomodulator

Abstract

Keywords

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