Sympathetic and adrenocorticoid influences on diet-induced thermogenesis and brown fat activity in the rat

N. J. Rothwell, M. J. Stock

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. Bilateral adrenalectomy markedly reduced body weight and energy gain and energetic efficiency of adult cafeteria-fed rats but enhanced the thermogenic response to food and stimulated brown fat activity. 2. 2. These changes were totally prevented by replacement of the animals with corticosterone (1 mg/ rat/day). 3. 3. Unilateral denervation of the sympathetic nerves supplying the interscapular brown adipose tissue abolished the enhanced activity resulting from adrenalectomy and inhibited thermogenic activity in brown fat from cafeteria rats with intact adrenals, but had no effect in adrenalectomised animals treated with a high dose of corticosterone. © 1984.
Original languageEnglish
Pages (from-to)575-579
Number of pages4
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume79
Issue number4
Publication statusPublished - 1984

Fingerprint

Dive into the research topics of 'Sympathetic and adrenocorticoid influences on diet-induced thermogenesis and brown fat activity in the rat'. Together they form a unique fingerprint.

Cite this