Symptom severity and its effect on health-related quality of life over time in patients with pulmonary hypertension: a longitudinal cohort study: A multisite longitudinal cohort study

Janelle Yorke, Christi Deaton, Malcolm Campbell, Linda McGowen, Paul Sephton, David G. Kiely, Iain Armstrong

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The aim of this cohort study was to examine health-related quality of life (HRQoL) and symptomatology in patients with pulmonary hypertension (PH) and explore factors that influence its evolution over time.
Methods: A prospective longitudinal multi-site cohort study. Participants were recruited from specialist UK PH centres, and completed a questionnaire pack at baseline, 6, 12, and 18 months to assess HRQoL (emPHasis-10), dyspnoea, fatigue, sleep, anxiety, and depression.
Results: 185 patients entered the study at baseline and 126 (68%) completed month 18. At baseline patients had significant impairment of HRQoL, anxiety, depression, dyspnea and severe fatigue. No significant changes, apart from a reduction in the HADS-Anxiety score (p=0.04), were observed over 18 months. Depression and dyspnoea were predictors of HRQoL (p=0.002 and p=0.03, respectively). Oxygen use was also associated with diminished HRQoL and increased symptom severity.
Conclusion: Patients with PH experience high levels of symptom severity and the negative impact on HRQoL was unchanged over time. The use of oxygen therapy, in particular, was associated with a significant impact on HRQoL. Further study of factors impacting HRQoL and interventions that target a combination of physiological and psychosocial consequences of living with PH are needed.
Original languageEnglish
Article numbere000263
JournalBMJ Open Respiratory Research
Volume5
Issue number1
Early online date1 Mar 2018
DOIs
Publication statusPublished - 2018

Keywords

  • primary pulmonary hypertension
  • psychology

Research Beacons, Institutes and Platforms

  • Manchester Institute for Collaborative Research on Ageing

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