Abstract
The prevalence of autism spectrum disorder (ASD) in many genetic disorders is well documented but not as yet in Mucopolysaccharidosis type III (MPS III). MPS III is a recessively inherited metabolic disorder and evidence suggests that symptoms of ASD present in MPS III. This systematic review examined the extant literature on the symptoms of ASD in MPS III and quality assessed a total of 16 studies. Results indicated that difficulties within speech, language and communication consistent with ASD were present in MPS III, whilst repetitive and restricted behaviours and interests were less widely reported. The presence of ASD-like symptoms can result in late diagnosis or misdiagnosis of MPS III and prevent opportunities for genetic counselling and the provision of treatments.
Original language | English |
---|---|
Pages (from-to) | 3620-3633 |
Number of pages | 13 |
Journal | Journal of Autism and Developmental Disorders |
Volume | 47 |
Issue number | 11 |
Early online date | 30 Aug 2017 |
DOIs | |
Publication status | Published - 30 Aug 2017 |
Keywords
- Mucopolysacchardosis, Lysosomal storage disorder, Developmental disorder, ASD, Speech/language delay, Behavioural difficulties
Fingerprint
Dive into the research topics of 'Symptoms of Autism Spectrum Disorder (ASD) in individuals with Mucopolysaccaride Disease Type III (Sanfilippo Syndrome): A systematic review'. Together they form a unique fingerprint.Student theses
-
The Symptomology of Autism Spectrum Disorder (ASD) in Children with Mucopolysaccharidosis Type III (MPS III)
Wolfenden, C. (Author), Calam, R. (Supervisor) & Wittkowski, A. (Supervisor), 31 Dec 2017Student thesis: Doctor of Clinical Psychology
File