Synchronous apoptosis in established tumors leads to the induction of adaptive immunity

Research output: Contribution to journalArticlepeer-review

Abstract

Understanding the immune response to the death of malignant cells is critical for the development of therapeutic strategies designed to stimulate the immune system against cancer. We have developed an inducible caspase-3-mediated death switch model to explore the effects of apoptosis on the host immune system, demonstrating thatthe synchronous apoptotic demise of established tumors can be immunogenic and elicit anticancer T-cell responses.© 2013 Landes Bioscience.
Original languageEnglish
Article numbere24501
JournalOncoImmunology
Volume2
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Apoptosis
  • Cancer
  • Caspase 3
  • Death switch
  • HMGB1
  • Immunogenic cell death

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