Synergistic effect in drug solubility by new binary micelles of poly(ϵ-caprolactone)-poly(ethylene oxide) and F127®

Lillian M.U. Dutra; Igor M. Cavalcante; Débora H. A. de Brito; Ícaro G.P. Vieira; Maria T.S. Trevisan; Maria E. N. P. Ribeiro; Stephen G. Yeates; Nógila M.P.S. Ricardo

doi:10.21577/0103-5053.20160302

Synergistic effect in drug solubility by new binary micelles of poly(ϵ-caprolactone)-poly(ethylene oxide) and F127®

Lillian M.U. Dutra, Igor M. Cavalcante, Débora H. A. de Brito, Ícaro G.P. Vieira, Maria T.S. Trevisan, Maria E. N. P. Ribeiro, Stephen G. Yeates, Nógila M.P.S. Ricardo

Research output: Contribution to journal › Article › peer-review

Abstract

Binary mixtures of block copolymers E₁₁₄CL₂₀ and E₉₇P₆₉E₉₇ (F127®) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E₁₁₄CL₂₀ mixtures (30-50 wt.%) were observed by addition of the diblock E₁₁₄CL₂₀, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.

Original language	English
Pages (from-to)	1341-1346
Number of pages	6
Journal	Journal of the Brazilian Chemical Society
Volume	28
Issue number	7
DOIs	https://doi.org/10.21577/0103-5053.20160302
Publication status	Published - 17 Nov 2016

Keywords

Binary mixtures
Drug solubility
Poly(ϵ-caprolactone)-poly(ethylene oxide)
Synergistic effect

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Dutra, L. M. U., Cavalcante, I. M., Brito, D. H. A. D., Vieira, Í. G. P., Trevisan, M. T. S., Ribeiro, M. E. N. P., Yeates, S. G., & Ricardo, N. M. P. S. (2016). Synergistic effect in drug solubility by new binary micelles of poly(ϵ-caprolactone)-poly(ethylene oxide) and F127®. Journal of the Brazilian Chemical Society, 28(7), 1341-1346. https://doi.org/10.21577/0103-5053.20160302

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title = "Synergistic effect in drug solubility by new binary micelles of poly(ϵ-caprolactone)-poly(ethylene oxide) and F127{\textregistered}",

abstract = "Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127{\textregistered}) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.",

keywords = "Binary mixtures, Drug solubility, Poly(ϵ-caprolactone)-poly(ethylene oxide), Synergistic effect",

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doi = "10.21577/0103-5053.20160302",

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AU - Dutra, Lillian M.U.

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AU - Brito, Débora H. A. de

AU - Vieira, Ícaro G.P.

AU - Trevisan, Maria T.S.

AU - Ribeiro, Maria E. N. P.

AU - Yeates, Stephen G.

AU - Ricardo, Nógila M.P.S.

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AB - Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127®) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reaching the best enhancement of drug solubility for mangiferin and carbamazepine.

KW - Binary mixtures

KW - Drug solubility

KW - Poly(ϵ-caprolactone)-poly(ethylene oxide)

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Synergistic effect in drug solubility by new binary micelles of poly(ϵ-caprolactone)-poly(ethylene oxide) and F127®

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Keywords

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