Synthesis and antibacterial activity of novel 2-(arylimino)thiazolidin-4-one and 2-(benzylidenehydrazono)-3-arylthiazolidin-4-one derivatives

Ebaa M. El-Hossary, Yassin M. Nissan, Katharina Edkins, Heike Bruhn

Research output: Contribution to journalArticlepeer-review

Abstract

The ongoing spread of multidrug-resistant bacteria demands an intensive search for new antibacterial agents. In the present study, a series of new 1,3-thiazolidin-4-ones has been synthesized and investigated for its in vitro antibacterial activity. The most potent antibacterial compound 4c was found to be active, at low micromolar range, against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and the pneumonic plague causative agent Yersinia pestis with minimum inhibitory concentrations of 5 μM, 2.5 μM, 2.5 μM and 5 μM, respectively. Compound 4c showed the ability to kill E. faecalis JH212 strain with a minimum bactericidal concentration of 5 μM. Furthermore, compounds 9b and 10a inhibited the biofilm formation in S. epidermidis, where they showed 70% to 80% inhibition at a concentration of 40 μM.
Original languageEnglish
Pages (from-to)7-17
Number of pages11
JournalJournal of Applied Pharmaceutical Science
Volume6
Issue number5
DOIs
Publication statusPublished - 28 May 2016

Keywords

  • 1,3-Thiazolidin-4-one
  • Antibacterial activity
  • Biofilm formation
  • Minimum bactericidal concentration
  • Minimum inhibitory concentration

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