Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues

Steven M. Miles, Robin J. Leatherbarrow, Stephen P. Marsden, William J. Coates

    Research output: Contribution to journalArticlepeer-review


    Bowman-Birk inhibitor analogues containing 2, 3 and 4-carbon analogues of the natural disulfide were synthesised via solid phase microwave-assisted RCM and found to have Ki values against chymotrypsin in the low to submicromolar range, the best replacement for the disulflde arising from the linkage by RCM of two L-homoallylglycine residues.
    Original languageEnglish
    Pages (from-to)281-283
    Number of pages2
    JournalOrganic and Biomolecular Chemistry
    Issue number3
    Publication statusPublished - 7 Feb 2004


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