Abstract
Bowman-Birk inhibitor analogues containing 2, 3 and 4-carbon analogues of the natural disulfide were synthesised via solid phase microwave-assisted RCM and found to have Ki values against chymotrypsin in the low to submicromolar range, the best replacement for the disulflde arising from the linkage by RCM of two L-homoallylglycine residues.
Original language | English |
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Pages (from-to) | 281-283 |
Number of pages | 2 |
Journal | Organic and Biomolecular Chemistry |
Volume | 2 |
Issue number | 3 |
Publication status | Published - 7 Feb 2004 |