Synthesis and characterization of a smart contrast agent sensitive to calcium

Nikos Logothetis; Kirti Dhingra; Martin E. Maier; Michael Beyerlein; Goran Angelovski; Nikos K. Logothetis

doi:10.1039/b801975d

Synthesis and characterization of a smart contrast agent sensitive to calcium

Nikos Logothetis, Kirti Dhingra, Martin E. Maier, Michael Beyerlein, Goran Angelovski, Nikos K. Logothetis

Research output: Contribution to journal › Article › peer-review

Abstract

A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows ∼100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements. © The Royal Society of Chemistry.

Original language	English
Pages (from-to)	3444-3446
Number of pages	2
Journal	Chemical Communications
Issue number	29
DOIs	https://doi.org/10.1039/b801975d
Publication status	Published - 2008

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10.1039/b801975d

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title = "Synthesis and characterization of a smart contrast agent sensitive to calcium",

abstract = "A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows ∼100\% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements. {\textcopyright} The Royal Society of Chemistry.",

author = "Nikos Logothetis and Kirti Dhingra and Maier, \{Martin E.\} and Michael Beyerlein and Goran Angelovski and Logothetis, \{Nikos K.\}",

year = "2008",

doi = "10.1039/b801975d",

language = "English",

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journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Synthesis and characterization of a smart contrast agent sensitive to calcium

AU - Logothetis, Nikos

AU - Dhingra, Kirti

AU - Maier, Martin E.

AU - Beyerlein, Michael

AU - Angelovski, Goran

AU - Logothetis, Nikos K.

PY - 2008

Y1 - 2008

N2 - A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows ∼100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements. © The Royal Society of Chemistry.

AB - A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows ∼100% relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements. © The Royal Society of Chemistry.

UR - https://www.scopus.com/pages/publications/47549086905

U2 - 10.1039/b801975d

DO - 10.1039/b801975d

M3 - Article

C2 - 18633517

SN - 1359-7345

SP - 3444

EP - 3446

JO - Chemical Communications

JF - Chemical Communications

IS - 29

ER -

Synthesis and characterization of a smart contrast agent sensitive to calcium

Abstract

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