Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica

A. Bumb; M. W. Brechbiel; P. L. Choyke; L. Fugger; A. Eggeman; D. Prabhakaran; J. Hutchinson; P. J. Dobson

doi:10.1088/0957-4484/19/33/335601

Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica

A. Bumb, M. W. Brechbiel, P. L. Choyke, L. Fugger, A. Eggeman, D. Prabhakaran, J. Hutchinson, P. J. Dobson

Research output: Contribution to journal › Article › peer-review

Abstract

Ultra-small superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (∼2 nm) layers of silica. The particles have been characterized for size, diffraction pattern, surface charge, and magnetic properties. This rapid and economical synthesis has a number of industrial applications; however, the silica-coated particles have been optimized for use in medical applications such as magnetic resonance contrast agents and biosensors, and in DNA capturing, bioseparation and enzyme immobilization.

Original language	English
Article number	335601
Journal	Nanotechnology
Volume	19
Issue number	33
DOIs	https://doi.org/10.1088/0957-4484/19/33/335601
Publication status	Published - 20 Aug 2008

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AU - Bumb, A.

AU - Brechbiel, M. W.

AU - Choyke, P. L.

AU - Fugger, L.

AU - Eggeman, A.

AU - Prabhakaran, D.

AU - Hutchinson, J.

AU - Dobson, P. J.

PY - 2008/8/20

Y1 - 2008/8/20

N2 - Ultra-small superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (∼2 nm) layers of silica. The particles have been characterized for size, diffraction pattern, surface charge, and magnetic properties. This rapid and economical synthesis has a number of industrial applications; however, the silica-coated particles have been optimized for use in medical applications such as magnetic resonance contrast agents and biosensors, and in DNA capturing, bioseparation and enzyme immobilization.

AB - Ultra-small superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (∼2 nm) layers of silica. The particles have been characterized for size, diffraction pattern, surface charge, and magnetic properties. This rapid and economical synthesis has a number of industrial applications; however, the silica-coated particles have been optimized for use in medical applications such as magnetic resonance contrast agents and biosensors, and in DNA capturing, bioseparation and enzyme immobilization.

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VL - 19

JO - Nanotechnology

JF - Nanotechnology

IS - 33

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ER -

Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica

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