Synthesis and cytotoxic activity of thiazolyl indolequinones

Christopher J. Moody; Jonathan R A Roffey; Elizabeth Swann; Stacey Lockyer; Susan Houlbrook; Ian J. Stratford

Synthesis and cytotoxic activity of thiazolyl indolequinones

Christopher J. Moody, Jonathan R A Roffey, Elizabeth Swann, Stacey Lockyer, Susan Houlbrook, Ian J. Stratford

Research output: Contribution to journal › Article › peer-review

Abstract

A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determined in the human breast cancer SKBr3 cell line. Selected compounds were also studied in human lung carcinoma A549 and PV9 cell lines. In addition, some compounds were evaluated for their possible bioreductive action by determining their cytotoxicity towards V79 Chinese hamster lung fibroblasts in air and under anerobic (hypoxic) conditions.

Original language	English
Pages (from-to)	577-589
Number of pages	12
Journal	Anti-Cancer Drugs
Volume	10
Issue number	6
Publication status	Published - 1999

Keywords

Bioreductive
Cytotoxicity
Indole
Quinone
Thiazole

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{0ad10f74010145cf8632343e5d2121da,

title = "Synthesis and cytotoxic activity of thiazolyl indolequinones",

abstract = "A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determined in the human breast cancer SKBr3 cell line. Selected compounds were also studied in human lung carcinoma A549 and PV9 cell lines. In addition, some compounds were evaluated for their possible bioreductive action by determining their cytotoxicity towards V79 Chinese hamster lung fibroblasts in air and under anerobic (hypoxic) conditions.",

keywords = "Bioreductive, Cytotoxicity, Indole, Quinone, Thiazole",

author = "Moody, {Christopher J.} and Roffey, {Jonathan R A} and Elizabeth Swann and Stacey Lockyer and Susan Houlbrook and Stratford, {Ian J.}",

year = "1999",

language = "English",

volume = "10",

pages = "577--589",

journal = "Anti-Cancer Drugs",

issn = "1473-5741",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

TY - JOUR

T1 - Synthesis and cytotoxic activity of thiazolyl indolequinones

AU - Moody, Christopher J.

AU - Roffey, Jonathan R A

AU - Swann, Elizabeth

AU - Lockyer, Stacey

AU - Houlbrook, Susan

AU - Stratford, Ian J.

PY - 1999

Y1 - 1999

N2 - A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determined in the human breast cancer SKBr3 cell line. Selected compounds were also studied in human lung carcinoma A549 and PV9 cell lines. In addition, some compounds were evaluated for their possible bioreductive action by determining their cytotoxicity towards V79 Chinese hamster lung fibroblasts in air and under anerobic (hypoxic) conditions.

AB - A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determined in the human breast cancer SKBr3 cell line. Selected compounds were also studied in human lung carcinoma A549 and PV9 cell lines. In addition, some compounds were evaluated for their possible bioreductive action by determining their cytotoxicity towards V79 Chinese hamster lung fibroblasts in air and under anerobic (hypoxic) conditions.

KW - Bioreductive

KW - Cytotoxicity

KW - Indole

KW - Quinone

KW - Thiazole

M3 - Article

SN - 1473-5741

VL - 10

SP - 577

EP - 589

JO - Anti-Cancer Drugs

JF - Anti-Cancer Drugs

IS - 6

ER -

Synthesis and cytotoxic activity of thiazolyl indolequinones

Abstract

Keywords

UN SDGs

Fingerprint

Cite this