Synthesis and evaluation of mimetics of UDP and UDP-α-D-galactose, dTDP and dTDP-α-D-glucose with monosaccharides replacing the key pyrophosphate unit

L. Ballell; R.J. Young; R.A. Field

doi:10.1039/b500418g

Synthesis and evaluation of mimetics of UDP and UDP-α-D-galactose, dTDP and dTDP-α-D-glucose with monosaccharides replacing the key pyrophosphate unit

L. Ballell, R.J. Young, R.A. Field

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

A series of 5′-O-glycosyl-uridine and thymidine derivatives have been prepared as potential mimics of sugar nucelotides and nucleotide-diphosphates. These compounds proved not to be inhibitors of bovine β-1,4-galactosyltransferase although some showed moderate inhibition of Salmonella dTDP-α-D-glucose 4,6-dehydratase (RmlB).

Original language	Undefined
Pages (from-to)	1109-1115
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	3
Issue number	6
DOIs	https://doi.org/10.1039/b500418g
Publication status	Published - 21 Feb 2005

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Manchester Institute of Biotechnology

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10.1039/b500418g

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AU - Field, R.A.

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AB - A series of 5′-O-glycosyl-uridine and thymidine derivatives have been prepared as potential mimics of sugar nucelotides and nucleotide-diphosphates. These compounds proved not to be inhibitors of bovine β-1,4-galactosyltransferase although some showed moderate inhibition of Salmonella dTDP-α-D-glucose 4,6-dehydratase (RmlB).

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Synthesis and evaluation of mimetics of UDP and UDP-α-D-galactose, dTDP and dTDP-α-D-glucose with monosaccharides replacing the key pyrophosphate unit

Abstract

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