Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins

Jeffrey Walton, Gordon J T Tiddy, Simon J. Webb

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A series of new sugar-based nonionic surfactants have been synthesized and their lyotropic liquid crystalline properties characterized. When in contact with water, these surfactants formed a range of lyotropic liquid crystalline phases, including cubic, hexagonal, and lamellar, as well as a separate micellar phase. These are features that have promise for the crystallization of integral membrane proteins. © 2005 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)737-741
    Number of pages4
    JournalTetrahedron Letters
    Volume47
    Issue number5
    DOIs
    Publication statusPublished - 30 Jan 2006

    Keywords

    • Liquid crystals (lyotropic
    • synthesis and lyotropic phase behavior of novel nonionic surfactants for crystn. of integral membrane proteins)
    • Proteins Role: PRP (Properties) (membrane, integral
    • Surfactants (nonionic
    • Crystallization (synthesis and lyotropic phase behavior of novel nonionic surfactants for crystn. of integral membrane proteins)
    • Alditols
    • Monosaccharides Role: PRP (Properties), SPN (Synthetic preparation), PREP (Preparation) (synthesis and lyotropic phase behavior of novel nonionic surfactants for crystn. of integral membrane proteins)
    • lyotropic surfactant crystn membrane protein liq cryst alditol monosaccharide

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