Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

Charlotte J Mable; Lee A. Fielding; Mathew J Derry; Oleksandr O Mykhaylyk; Pierre Chambon; Steven P. Armes

doi:10.1039/C7SC04788F

Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

Charlotte J Mable, Lee A. Fielding, Mathew J Derry, Oleksandr O Mykhaylyk, Pierre Chambon, Steven P. Armes

Research output: Contribution to journal › Article › peer-review

Abstract

A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.

Original language	English
Pages (from-to)	1454-1463
Journal	Chemical Science
Early online date	13 Dec 2017
DOIs	https://doi.org/10.1039/C7SC04788F
Publication status	Published - 2018

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title = "Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution",

abstract = "A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.",

author = "Mable, {Charlotte J} and Fielding, {Lee A.} and Derry, {Mathew J} and Mykhaylyk, {Oleksandr O} and Pierre Chambon and Armes, {Steven P.}",

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doi = "10.1039/C7SC04788F",

language = "English",

pages = "1454--1463",

journal = "Chemical Science",

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publisher = "Royal Society of Chemistry",

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T1 - Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

AU - Mable, Charlotte J

AU - Fielding, Lee A.

AU - Derry, Mathew J

AU - Mykhaylyk, Oleksandr O

AU - Chambon, Pierre

AU - Armes, Steven P.

PY - 2018

Y1 - 2018

N2 - A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.

AB - A series of pH-responsive all-methacrylic ABC triblock copolymer vesicles were prepared from precursor diblock copolymer vesicles via RAFT seeded emulsion polymerisation. Microphase separation between the two hydrophobic membrane-forming B and C blocks produced a distinctive framboidal morphology, for which the mean globule size can be tuned by adjusting the triblock copolymer composition. These vesicles remain intact at neutral pH, but undergo irreversible dissociation on addition of acid as a result of protonation of the tertiary amine groups located within the third block. Small-angle X-ray scattering (SAXS) was utilised to characterise the morphologies formed at pH 8 and pH 3. According to time-resolved SAXS studies, the acid-induced dissociation of these pH-responsive framboidal vesicles involves appreciable membrane swelling within 50 ms and is complete.

U2 - 10.1039/C7SC04788F

DO - 10.1039/C7SC04788F

M3 - Article

SN - 2041-6520

SP - 1454

EP - 1463

JO - Chemical Science

JF - Chemical Science

ER -

Synthesis and pH-responsive dissociation of framboidal ABC triblock copolymer vesicles in aqueous solution

Abstract

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